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一种靶向内质网的远红光BODIPY染料高效光诱导产生活性氧物种。

Efficient light-induced reactive oxygen species production from a far-red ER-targeting BODIPY dye.

作者信息

Swavey Shawn, Quentel Arnaud, Grzesiak Matthew, Hawkins Cate, Vidi Pierre-Alexandre

机构信息

Department of Chemistry, University of Dayton Dayton OH 45469 USA

Laboratoire InGenO, Institut de Cancérologie de l'Ouest Angers 49055 France.

出版信息

RSC Adv. 2024 Dec 9;14(52):38796-38805. doi: 10.1039/d4ra05603e. eCollection 2024 Dec 3.

DOI:10.1039/d4ra05603e
PMID:39654916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11626712/
Abstract

Generation of reactive oxygen species (ROS) within the ER evokes stress leading to immunogenic cell death. A red light activated BODIPY dye capable of subcellular localization within the ER producing high quantum yields of ROS is reported. The ability of this dye to act as a photodynamic therapy (PDT) agent in breast cancer cells suggests promising organelle-targeted therapeutics.

摘要

内质网内活性氧（ROS）的产生会引发应激反应，导致免疫原性细胞死亡。据报道，一种红光激活的BODIPY染料能够在内质网内进行亚细胞定位，并产生高量子产率的ROS。这种染料在乳腺癌细胞中作为光动力疗法（PDT）药物的能力表明，有前景的细胞器靶向治疗方法有望实现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/98b821414381/d4ra05603e-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/f3b90a9d1397/d4ra05603e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/7f232a669859/d4ra05603e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/cd0e221861a2/d4ra05603e-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/681e35c0cade/d4ra05603e-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/4819592fa233/d4ra05603e-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/3f3aac9324c5/d4ra05603e-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/98b821414381/d4ra05603e-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/f3b90a9d1397/d4ra05603e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/7f232a669859/d4ra05603e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/cd0e221861a2/d4ra05603e-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/681e35c0cade/d4ra05603e-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/4819592fa233/d4ra05603e-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/3f3aac9324c5/d4ra05603e-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a8/11626712/98b821414381/d4ra05603e-f7.jpg

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