Population Health and Optimal Health Practices Research Unit, CHU de Québec-Université Laval, Québec, Canada.
Institut National de Santé Publique du Québec (INSPQ), Québec, Canada.
Pediatr Res. 2017 Sep;82(3):416-422. doi: 10.1038/pr.2017.115. Epub 2017 Jun 7.
BackgroundObesity and insulin resistance are linked with mood disorders, and elevated concentrations of branched-chain (BCAAs) and aromatic amino acids (AAAs). Our study aimed to prospectively assess the relationship between childhood plasma BCAAs and AAAs, and behavioral problems in young Inuit from Nunavik.MethodsWe analyzed data on 181 children (with a mean age of 11.4 years at baseline) involved in the Nunavik Child Development Study. Plasma BCAA and AAA concentrations were measured in childhood (2005-2010). BCAA/AAA tertiles-the ratio of total BCAAs to AAAs-were considered as surrogate categorical independent variables. Behavioral problems were assessed with the Youth Self-Report (YSR) from the Child Behavior Checklist about 7 years later during adolescence (2013-2016). ANOVA ascertained relationships between BCAA/AAA tertiles and YSR outcomes.ResultsAscending BCAA/AAA tertiles were positively associated (P<0.05) with somatic complaint scores. Scores of somatic complaints syndrome were significantly higher (P <0.05) with increasing BCAA/AAA tertiles among both normal and overweight/obese participants.ConclusionOur results suggest that higher BCAA/AAA ratios in childhood are significantly associated with somatic complaints in adolescence.
肥胖和胰岛素抵抗与情绪障碍有关，并且与支链氨基酸（BCAA）和芳香族氨基酸（AAA）的浓度升高有关。我们的研究旨在前瞻性评估努纳武特因纽特儿童童年血浆支链氨基酸和芳香族氨基酸与行为问题之间的关系。
我们分析了参与努纳武特儿童发展研究的 181 名儿童（基线时平均年龄为 11.4 岁）的数据。在儿童时期（2005-2010 年）测量了血浆支链氨基酸和芳香族氨基酸的浓度。将支链氨基酸/芳香族氨基酸三分位数（总支链氨基酸与芳香族氨基酸的比值）作为替代分类独立变量进行考虑。大约 7 年后，在青春期（2013-2016 年）使用儿童行为检查表的青少年自我报告（YSR）评估行为问题。方差分析确定了支链氨基酸/芳香族氨基酸三分位数与 YSR 结果之间的关系。
支链氨基酸/AAA 三分位数呈上升趋势与躯体抱怨评分呈正相关（P<0.05）。在正常体重和超重/肥胖参与者中，随着支链氨基酸/AAA 三分位数的增加，躯体抱怨综合征的评分显著升高（P <0.05）。
我们的研究结果表明，儿童时期较高的支链氨基酸/AAA 比值与青春期的躯体抱怨显著相关。
