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患有致残性慢性疼痛的儿童和青少年的临床和经济长期治疗结果。

Clinical and Economic Long-Term Treatment Outcome of Children and Adolescents with Disabling Chronic Pain.

机构信息

Department of Children's Pain Therapy and Paediatric Palliative Care, German Paediatric Pain Centre, Children's and Adolescents' Hospital Datteln, Witten/Herdecke University, Faculty of Health, School of Medicine, Witten, Germany.

出版信息

Pain Med. 2018 Jan 1;19(1):16-28. doi: 10.1093/pm/pnx067.

Abstract

OBJECTIVE

Disabling pediatric chronic pain is accompanied by a significant burden to those affected and by high societal costs. Furthermore, it bears the risk of aggravation into adulthood. Studies have shown intensive interdisciplinary pain treatment to result in short-term positive effects on pain-related and psychological outcomes. In this study, we aimed to prove the stability of the long-term effects of intensive interdisciplinary pain treatment four years after treatment.

METHODS

This longitudinal observational study followed adolescents who had received intensive interdisciplinary pain treatment over four years. We defined a combined end point, overall improvement (pain intensity, pain-related disability, and school/work absence), and investigated three additional psychological outcome domains (anxiety, depression, pain catastrophizing). We also examined changes to economic parameters (health care utilization, subjective financial burden) and their relationship to patient improvement.

RESULTS

Similar patterns were observed for pain-related and psychological outcome domains, with data showing statistically and clinically significant reductions from admission to four-year follow-up. These positive effects were stable from one- to four-year follow-up. Approximately 60% of the adolescents showed an overall long-term improvement. Older age was found to be a risk factor for treatment failure. Economic parameters decreased statistically significantly, particularly for those with an overall improvement of the chronic pain disorder.

CONCLUSIONS

The results of this study support the long-term effectiveness of intensive interdisciplinary pain treatment and indicate that it can interrupt pain chronification. Future research is warranted to investigate why some of the adolescents did not show improvement and to allow for a more individualized treatment.

摘要

目的

儿童慢性疼痛的致残性给患者及其家庭带来沉重负担,同时也给社会带来巨大经济负担。此外,儿童慢性疼痛还可能发展为成年期疼痛。研究表明,强化的多学科疼痛治疗可在短期内改善疼痛相关和心理结局。本研究旨在证明强化的多学科疼痛治疗 4 年后长期疗效的稳定性。

方法

本纵向观察性研究纳入了接受强化的多学科疼痛治疗 4 年的青少年患者。我们定义了一个综合终点,即整体改善(疼痛强度、疼痛相关残疾和缺课/旷工),并调查了另外三个心理结局领域(焦虑、抑郁、疼痛灾难化)。我们还检查了经济参数(卫生保健利用、主观经济负担)的变化及其与患者改善的关系。

结果

疼痛相关和心理结局领域的结果模式相似,数据显示从入院到 4 年随访时,疼痛强度、疼痛相关残疾和缺课/旷工均显著降低,且具有统计学和临床意义。这些积极的影响在 1 年至 4 年的随访中是稳定的。约 60%的青少年表现出长期整体改善。年龄较大是治疗失败的危险因素。经济参数具有统计学显著下降,尤其是在慢性疼痛障碍整体改善的患者中。

结论

本研究结果支持强化的多学科疼痛治疗的长期疗效,并表明其可阻断疼痛的慢性化进程。需要进一步研究以探讨为什么一些青少年没有改善,并允许进行更个体化的治疗。

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