Demir Berat, Sarı Murat, Binnetoglu Adem, Yumusakhuylu Ali Cemal, Filinte Deniz, Tekin İshak Özel, Bağlam Tekin, Batman Abdullah Çağlar
Department of Otorhinolaryngology-Head and Neck Surgery, Pendik Training and Research Hospital, Marmara University Medical Faculty, Mimar Sinan Caddesi No. 41, Fevzi Cakmak Mahallesi, Ust Kaynarca-Pendik, 34899 Istanbul, Turkey.
Department of Otorhinolaryngology-Head and Neck Surgery, Pendik Training and Research Hospital, Marmara University Medical Faculty, Mimar Sinan Caddesi No. 41, Fevzi Cakmak Mahallesi, Ust Kaynarca-Pendik, 34899 Istanbul, Turkey.
Auris Nasus Larynx. 2018 Apr;45(2):301-305. doi: 10.1016/j.anl.2017.04.005. Epub 2017 May 6.
The present study aimed to compare the effects of bacterial cellulose used for closure of pharyngocutaneous fistulae, a complication of total laryngectomy, with those of primary sutures in a rat model.
Thirty female Sprague-Dawley underwent experimental pharyngoesophagotomy and were grouped depending on the material used for pharyngocutaneous fistula closure: group I, which received primary sutures alone, group II, which received bacterial cellulose alone; and group III, which received both. After 7 days, the rats were sacrificed. Pharyngocutaneous fistula development was assessed, the gross wound was inspected, and histological examination was conducted.
Pharyngocutaneous fistulae developed in 12 rats (41%) in all: 6 from group I (21%), 4 from group II (14%) and 2 from group III (7%).
Fibroblast density and inflammatory cell infiltration were significantly greater in group III than group I. We concluded that bacterial cellulose may be useful for pharyngocutaneous fistula closure.
本研究旨在比较在大鼠模型中，用于闭合全喉切除术后并发症咽皮瘘的细菌纤维素与一期缝合的效果。
30只雌性斯普拉格-道利大鼠接受实验性咽食管切开术，并根据用于闭合咽皮瘘的材料进行分组：第一组仅接受一期缝合；第二组仅接受细菌纤维素；第三组接受两者。7天后，处死大鼠。评估咽皮瘘的发生情况，检查伤口大体情况，并进行组织学检查。
总共12只大鼠（41%）发生了咽皮瘘：第一组6只（21%），第二组4只（14%），第三组2只（7%）。
第三组的成纤维细胞密度和炎性细胞浸润明显高于第一组。我们得出结论，细菌纤维素可能有助于闭合咽皮瘘。
