触珠蛋白Hp2变异体促进中风幸存者心血管过早死亡。
Haptoglobin Hp2 Variant Promotes Premature Cardiovascular Death in Stroke Survivors.
作者信息
Ijäs Petra, Melkas Susanna, Saksi Jani, Jula Antti, Jauhiainen Matti, Oksala Niku, Pohjasvaara Tarja, Kaste Markku, Karhunen Pekka J, Lindsberg Perttu, Erkinjuntti Timo
机构信息
From the Clinical Neurosciences, Neurology (I.P., S.M., T.P., M.K., P.L., T.E.) and Research Programs Unit, Molecular Neurology, Biomedicum Helsinki (I.P., J.S., P.L.), University of Helsinki, Finland; Department of Neurology, Helsinki University Hospital, Finland (I.P., S.M., T.P., M.K., P.L., T.E.); National Institute for Health and Welfare, Helsinki, Finland (A.J., M.J.); Minerva Foundation Institute for Medical Research, Biomedicum, Helsinki, Finland (M.J.); School of Medicine, University of Tampere, Finland (N.O., P.J.K.); and FimLab Laboratories Ltd (N.O., P.J.K.) and Division of Vascular Surgery, Department of Surgery (N.O.), Tampere University Hospital, Finland.
出版信息
Stroke. 2017 Jun;48(6):1463-1469. doi: 10.1161/STROKEAHA.116.015683. Epub 2017 May 9.
BACKGROUND AND PURPOSE
Haptoglobin (Hp) is an acute phase plasma protein protecting tissues from oxidative damage. It exists in 2 variant alleles () giving rise to 3 protein isoforms with different biochemical properties and efficiency to limit oxidative stress. We previously found that variant is associated with stroke risk in the patients with carotid stenosis and the risk of ischemic cardiovascular events in a general population cohort. This study examined the hypothesis that Hp genotype is associated with general cardiovascular risk in patients with stroke.
METHODS
Hp was genotyped in SAM study (Helsinki Stroke Aging Memory, n=378). A total of 1426 individuals ascertained from a nationally representative cross-sectional health survey served as population controls.
RESULTS
Hp genotype frequencies were 15.6% (), 44.2% (), and 40.2% () in patients with stroke. During a mean of 7.5-year follow-up after first-ever stroke, carriers had a substantially higher rate of cardiac deaths (24.5% versus 8.5%; =0.006) and a trend toward more fatal strokes (23.5% versus 13.6%; =0.122). The combined risk of ischemic cardiovascular deaths was 2.4-fold higher among carriers (95% confidence interval, 1.28-4.43) after adjustment for major cardiovascular risk factors.
CONCLUSIONS
allele is associated with premature ischemic cardiovascular deaths after first-ever ischemic stroke.
背景与目的
触珠蛋白（Hp）是一种急性期血浆蛋白，可保护组织免受氧化损伤。它存在两种变异等位基因（），产生三种具有不同生化特性和限制氧化应激效率的蛋白质异构体。我们之前发现，在颈动脉狭窄患者中，变异与中风风险相关，在普通人群队列中与缺血性心血管事件风险相关。本研究检验了Hp基因型与中风患者总体心血管风险相关的假设。
方法
在SAM研究（赫尔辛基中风、衰老与记忆研究，n = 378）中对Hp进行基因分型。从一项具有全国代表性的横断面健康调查中确定的总共1426名个体作为人群对照。
结果
中风患者中Hp基因型频率分别为15.6%（）、44.2%（）和40.2%（）。在首次中风后的平均7.5年随访期间，携带者的心脏死亡发生率显著更高（24.5%对8.5%；P = 0.006），且有更多致命中风的趋势（23.5%对13.6%；P = 0.122）。在调整主要心血管危险因素后，携带者缺血性心血管死亡的综合风险高出2.4倍（95%置信区间，1.28 - 4.43）。
结论
等位基因与首次缺血性中风后的过早缺血性心血管死亡相关。
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