Churchfield Lewis A, George Athira, Tezcan F Akif
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0356, U.S.A.
Essays Biochem. 2017 May 9;61(2):245-258. doi: 10.1042/EBC20160068.
Inspired by the remarkable sophistication and complexity of natural metalloproteins, the field of protein design and engineering has traditionally sought to understand and recapitulate the design principles that underlie the interplay between metals and protein scaffolds. Yet, some recent efforts in the field demonstrate that it is possible to create new metalloproteins with structural, functional and physico-chemical properties that transcend evolutionary boundaries. This essay aims to highlight some of these efforts and draw attention to the ever-expanding scope of bioinorganic chemistry and its new connections to synthetic biology, biotechnology, supramolecular chemistry and materials engineering.
受天然金属蛋白卓越的复杂性和精巧性启发，蛋白质设计与工程领域传统上一直致力于理解和重现金属与蛋白质支架之间相互作用所依据的设计原则。然而，该领域最近的一些研究成果表明，有可能创造出具有超越进化界限的结构、功能和物理化学性质的新型金属蛋白。本文旨在突出其中的一些研究成果，并提请人们关注生物无机化学不断扩大的研究范围及其与合成生物学、生物技术、超分子化学和材料工程的新联系。
