Xiang Zichun, Li Linlin, Ren Lili, Guo Li, Xie Zhengde, Liu Chunyan, Li Taisheng, Luo Ming, Paranhos-Baccalà Gláucia, Xu Wenbo, Wang Jianwei
MOH Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing 100730, China.
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China.
Emerg Microbes Infect. 2017 May 10;6(5):e32. doi: 10.1038/emi.2017.14.
Human enterovirus 68 (EV-D68) is a rarely reported virus that has been linked to respiratory disease. In recent years, reports about EV-D68 infection have markedly increased worldwide. However, the epidemiological features of this emerging infection are not well understood. To evaluate the emerging EV-D68 epidemic, we isolated the circulating viral strain and investigated the seroprevalence of neutralizing antibodies (NAbs) in Beijing between 2004 and 2011. We found that the titers of EV-D68 NAbs were generally low in all age groups in sampled populations in 2004 but significantly higher in 2009. From 2007 to 2011, the NAbs against EV-D68 significantly increased over time. These findings indicate that EV-D68 has spread widely in the Chinese population in recent years, although only a limited number of cases were reported.
人肠道病毒68型（EV-D68）是一种鲜有报道的与呼吸道疾病相关的病毒。近年来，全球范围内关于EV-D68感染的报告显著增加。然而，这种新出现感染的流行病学特征尚未得到充分了解。为评估新出现的EV-D68疫情，我们分离了流行的病毒株，并调查了2004年至2011年期间北京地区中和抗体（NAbs）的血清流行率。我们发现，2004年抽样人群中所有年龄组的EV-D68 NAbs滴度普遍较低，但在2009年显著升高。从2007年到2011年，针对EV-D68的NAbs随时间显著增加。这些发现表明，尽管报告的病例数量有限，但近年来EV-D68已在中国人群中广泛传播。
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