Department of Virology 2, National Institute of Infectious Diseases, Tokyo, Japan.
Department of Infectious Disease Research, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Hyogo, Japan.
BMC Infect Dis. 2023 Jul 18;23(1):481. doi: 10.1186/s12879-023-08429-z.
Enterovirus D68 (EV-D68), belonging to Enterovirus D, is a unique human enterovirus mainly associated with common respiratory diseases. However, EV-D68 can cause severe respiratory diseases, and EV-D68 endemic is epidemiologically linked to current global epidemic of acute flaccid myelitis.
In this study, we measured neutralizing antibody titers against six clinical EV-D68 isolates in nine intravenous immune globulin (IVIG) products commercially available in Japan to assess their potential as therapeutic options for severe EV-D68 infection.
Seven IVIG products manufactured from Japanese donors contained high neutralizing antibody titers (IC = 0.22-85.01 µg/mL) against all six EV-D68 strains. Apparent differences in neutralizing titers among the six EV-D68 strains were observed for all IVIG products derived from Japanese and non-Japanese blood donors.
High levels of EV-D68-neutralizing antibodies in IVIG products manufactured from Japanese donors suggest that anti-EV-D68 antibodies are maintained in the Japanese donor population similarly as found in foreign blood donors. Apparent differences in neutralizing antibody titers against the six EV-D68 strains suggest distinct antigenicity among the strains used in this study regardless of the genetic similarity of EV-D68.
肠道病毒 D68（EV-D68）属于肠道病毒 D 组，是一种独特的人类肠道病毒，主要与常见的呼吸道疾病有关。然而，EV-D68 可引起严重的呼吸道疾病，并且 EV-D68 的流行与当前全球急性弛缓性脊髓炎的流行在流行病学上有关。
在这项研究中，我们测量了 9 种日本市售静脉注射免疫球蛋白（IVIG）产品对 6 种临床 EV-D68 分离株的中和抗体滴度，以评估其作为严重 EV-D68 感染治疗选择的潜力。
7 种来自日本供体的 IVIG 产品对所有 6 种 EV-D68 株均含有高中和抗体滴度（IC = 0.22-85.01 µg/mL）。来自日本和非日本供体的所有 IVIG 产品对 6 种 EV-D68 株的中和滴度均存在明显差异。
来自日本供体的 IVIG 产品中含有高水平的 EV-D68 中和抗体，表明抗 EV-D68 抗体在日本供体人群中得到维持，与国外供体相似。对 6 种 EV-D68 株的中和抗体滴度存在明显差异，表明本研究中使用的株之间存在明显的抗原性，而 EV-D68 的遗传相似性则不同。
