Department of Internal Medicine (I), Osaka Medical College, Takatsuki, Osaka, Japan.
Department of Mathematics, Osaka Medical College, Takatsuki, Osaka, Japan.
Sci Rep. 2017 May 9;7(1):1635. doi: 10.1038/s41598-017-01685-5.
Chemokines play an important role in the pathophysiology of dermatomyositis (DM) with interstitial pneumonia (IP). However, the relation between chemokines and the disease activity or prognosis of DM-IP has not been elucidated. We evaluated the serum C-C motif chemokine ligand (CCL) 2, Th1 chemokines (C-X-C motif chemokine ligand [CXCL] 9, CXCL10, CXCL11), and Th2 chemokine (CCL17) profiles of 30 patients, and examined the relation between these chemokines and the disease activity or prognosis of DM-IP. Initial serum CCL2 level was higher in the death group (P = 0.007). To determine the cut-off points effective as poor prognostic factors of DM-IP, ROC curve analysis was carried out on initial serum CCL2 level. The value that maximized the area under the ROC curve was 894 pg/mL (sensitivity: 100%, specificity: 70.8%). Serum CCL2, CXCL9, CXCL10, and CXCL11 levels were lower at 2 weeks after treatment initiation than before treatment. Serum CCL2, CXCL10, and CXCL11 levels at 2 weeks after treatment initiation were higher in the death group. Serum levels of chemokines such as CCL2, CXCL10, and CXCL11 may be possible biomarkers of disease activity and prognosis in DM-IP, and serum CCL2 level may be useful when deciding initial treatment.
趋化因子在皮肌炎（DM）伴间质性肺炎（IP）的病理生理学中起着重要作用。然而，趋化因子与 DM-IP 的疾病活动或预后之间的关系尚未阐明。我们评估了 30 例患者的血清 C-C 基序趋化因子配体（CCL）2、Th1 趋化因子（C-X-C 基序趋化因子配体[CXCL]9、CXCL10、CXCL11）和 Th2 趋化因子（CCL17）谱，并检查了这些趋化因子与 DM-IP 的疾病活动或预后之间的关系。死亡组初始血清 CCL2 水平较高（P=0.007）。为了确定作为 DM-IP 不良预后因素的有效截止值，对初始血清 CCL2 水平进行了 ROC 曲线分析。ROC 曲线下面积最大化的数值为 894 pg/mL（敏感性：100%，特异性：70.8%）。治疗开始后 2 周，血清 CCL2、CXCL9、CXCL10 和 CXCL11 水平低于治疗前。治疗开始后 2 周，死亡组血清 CCL2、CXCL10 和 CXCL11 水平较高。CCL2、CXCL10 和 CXCL11 等趋化因子的血清水平可能是 DM-IP 疾病活动和预后的潜在生物标志物，在决定初始治疗时，血清 CCL2 水平可能有用。
