Iida-Ueno Ayako, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi
Ayako Iida-Ueno, Masaru Enomoto, Akihiro Tamori, Norifumi Kawada, Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
World J Gastroenterol. 2017 Apr 21;23(15):2651-2659. doi: 10.3748/wjg.v23.i15.2651.
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and the second most common cause of cancer deaths worldwide. The top three causes of HCC are hepatitis B virus (HBV), hepatitis C virus (HCV), and alcoholic liver disease. Owing to recent advances in direct-acting antiviral agents, HCV can now be eradicated in almost all patients. HBV infection and alcoholic liver disease are expected, therefore, to become the leading causes of HCC in the future. However, the association between alcohol consumption and chronic hepatitis B in the progression of liver disease is less well understood than with chronic hepatitis C. The mechanisms underlying the complex interaction between HBV and alcohol are not fully understood, and enhanced viral replication, increased oxidative stress and a weakened immune response could each play an important role in the development of HCC. It remains controversial whether HBV and alcohol synergistically increase the incidence of HCC. Herein, we review the currently available literature regarding the interaction of HBV infection and alcohol consumption on disease progression.
肝细胞癌（HCC）是最常见的原发性肝癌类型，也是全球癌症死亡的第二大常见原因。导致HCC的三大原因是乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和酒精性肝病。由于直接作用抗病毒药物的最新进展，现在几乎所有患者的HCV都可以被根除。因此，HBV感染和酒精性肝病预计将成为未来HCC的主要原因。然而，与慢性丙型肝炎相比，酒精消费与慢性乙型肝炎在肝病进展中的关联尚不太清楚。HBV与酒精之间复杂相互作用的潜在机制尚未完全了解，病毒复制增强、氧化应激增加和免疫反应减弱可能在HCC的发生发展中各自发挥重要作用。HBV和酒精是否协同增加HCC的发病率仍存在争议。在此，我们综述了目前关于HBV感染与酒精消费在疾病进展中相互作用的现有文献。
