Zhao Yanyan, Song Chunhua, Ma Xiaokun, Ma Xiaojun, Wang Qingzhu, Ji Hongfei, Guo Feng, Qin Guijun
Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450052, China.
Int J Endocrinol. 2017;2017:9707284. doi: 10.1155/2017/9707284. Epub 2017 Apr 13.
. Family history of diabetes (FHD) and lifestyle are associated with type 2 diabetes (T2DM), but little is known about the FHD diet interactions. We aimed to analyze the interactions of FHD and lifestyle factors in Chinese T2DM onset. . This was a cross-sectional survey in central urban China ( = 1234 patients with T2DM and = 8615 non-T2DM subjects). The biological interactions, defined by Rothman interactions, between FHD and each dietary factor were analyzed by using the synergy index () scores. . After adjustment for age, gender, BMI, and WHR, a uniparental FHD (OR = 2.84, 95% CI: 2.36-3.42, < 0.001), a paternal history of FHD (OR = 2.53, 95% CI: 1.91-3.35, < 0.001), a maternal history of FHD (OR = 3.27, 95% CI: 2.67-4.02, < 0.001), a biparental history of FHD (OR = 5.26, 95% CI: 2.98-9.31, < 0.001), and a FHD, irrespective of the parent (OR = 3.59, 95% CI: 3.08-4.17, < 0.001), were associated with T2DM onset. There were significant interactions between FHD and consuming <15 g/d of potatoes ( = 1.54, 95% CI: 1.12-2.12), <8 g/d of poultry ( = 1.51, 95% CI: 1.04-2.17), <85 g/d of fresh fruits ( = 2.17, 95% CI: 1.63-2.88), and no freshly squeezed juice ( = 2.25, 95% CI: 1.46-3.49). . Risk of T2DM was synergistically affected by FHD and dietary habits. Nutrition educational intervention may decrease the prevalence of T2DM in the Chinese with FHD.
糖尿病家族史（FHD）和生活方式与2型糖尿病（T2DM）相关，但关于FHD与饮食的相互作用知之甚少。我们旨在分析FHD与生活方式因素在中国T2DM发病中的相互作用。 这是一项在中国中部城市进行的横断面调查（1234例T2DM患者和8615例非T2DM受试者）。使用协同指数（SI）评分分析FHD与每种饮食因素之间由Rothman相互作用定义的生物学相互作用。 在调整年龄、性别、BMI和腰臀比后，单亲FHD（OR = 2.84，95%CI：2.36 - 3.42，P < 0.001）、父亲FHD病史（OR = 2.53，95%CI：1.91 - 3.35，P < 0.001）、母亲FHD病史（OR = 3.27，95%CI：2.67 - 4.02，P < 0.001）、双亲FHD病史（OR = 5.26，95%CI：2.98 - 9.31，P < 0.001）以及无论父母的FHD（OR = 3.59，95%CI：3.08 - 4.17，P < 0.001）均与T2DM发病相关。FHD与每天食用<15克土豆（SI = 1.54，95%CI：1.12 - 2.12）、每天食用<8克家禽（SI = 1.51，95%CI：1.04 - 2.17）、每天食用<85克新鲜水果（SI = 2.17，95%CI：1.63 - 2.88）以及不饮用鲜榨果汁（SI = 2.25，95%CI：1.46 - 3.49）之间存在显著相互作用。 T2DM风险受到FHD和饮食习惯的协同影响。营养教育干预可能会降低有FHD的中国人中T2DM的患病率。
