Isoda Keiichi, Nakamura Tadashi, Yoshida Kensuke, Tamura Eiko, Atsuta Nami, Ishida Koichi, Takagi Yutaka, Mizutani Hitoshi
Department of Dermatology, Mie University, Mie, Japan.
R&D Development Research, Kao Corporation, Tokyo, Japan.
J Cosmet Dermatol. 2018 Feb;17(1):84-89. doi: 10.1111/jocd.12351. Epub 2017 May 9.
Many people use lip care products daily to prevent dry lips. However, some people, especially those with sensitive skin-consciousness, complain of various skin problems on their lips including contact dermatitis caused by lip care products. Dry lips have decreased water holding capacity and cutaneous barrier function as well as reduced stratum corneum ceramide levels. In this study, we investigated the usefulness of a newly formulated lip balm containing pseudo-ceramide for the dry lips of subjects with sensitive skin.
Thirty subjects with dry lips and sensitive skin-consciousness used the test lip balm more than twice a day for 4 weeks. Lip conditions were evaluated before and after 2 and 4 weeks.
Visual evaluation by a dermatologist showed that overall improvements were observed in all subjects as early as week 2. After 4 weeks of usage, 27% of the subjects were objectively judged as "markedly improved" and 60% of the subjects were judged as "improved". No adverse event developed throughout the test period, and all subjects were able to use the lip balm safely for 4 weeks. Usefulness was judged based on all evaluation items, and 27%, 70%, and 3% of the subjects were judged as "very useful," "useful," and "slightly useful," respectively. Ninety percentage of the subjects expressed improvement and acceptance of the lip balm.
Based on these results, the newly formulated lip balm containing pseudo-ceramide is very useful for the lip care of sensitive skin-conscious subjects as well as for daily use by healthy subjects.
许多人每天使用唇部护理产品以预防嘴唇干裂。然而，有些人，尤其是那些对皮肤敏感有认知的人，会抱怨唇部出现各种皮肤问题，包括由唇部护理产品引起的接触性皮炎。嘴唇干裂时，其持水能力、皮肤屏障功能下降，角质层神经酰胺水平降低。在本研究中，我们调查了一种新配方的含假神经酰胺的润唇膏对皮肤敏感受试者干裂唇部的效用。
30名嘴唇干裂且对皮肤敏感有认知的受试者每天使用测试润唇膏两次以上，持续4周。在2周和4周前后对唇部状况进行评估。
皮肤科医生的视觉评估显示，早在第2周时所有受试者的情况都有整体改善。使用4周后，27%的受试者被客观判定为“显著改善”，60%的受试者被判定为“改善”。在整个测试期间未出现不良事件，所有受试者都能安全使用该润唇膏4周。根据所有评估项目判断效用，27%、70%和3%的受试者分别被判定为“非常有用”、“有用”和“有点用”。90%的受试者表示该润唇膏有改善且可接受。
基于这些结果，新配方的含假神经酰胺的润唇膏对皮肤敏感有认知的受试者的唇部护理非常有用，也适合健康受试者日常使用。
