Vender Ronald B., Andriessen Anneke, Barankin Benjamin, Freiman Anatoli, Kyritsis Dimitrios, Mistos Loukia-Maria, Salsberg Jennifer, Amar Laetitia
J Drugs Dermatol. 2019 Jan 1;18(1):80-85.
Introduction: The skin of subjects with dry, flaking, and/or scaling conditions is characterized by decreased water and skin lipids content among other findings. It is well understood that daily use of gentle cleansers and moisturizers may help to restore and maintain an optimal skin barrier function. A cohort study of patients with dry skin was developed to evaluate efficacy of daily use of a ceramide containing cleanser and cream that also has salicylic acid. Methods: Thirty-five adults with mild-to-moderate dry skin conditions were recruited from four dermatology centers in Canada. With consent, the subjects received twice daily treatment with the ceramides containing cleanser and cream that also has salicylic acid. Physician and subject assessed skin condition comparing baseline versus (day 0) versus day 28 (end) was scored using the Dry skin classification scale and the Global Aesthetic Improvement Scale (GAIS). Subjects also rated satisfaction, product features, quality of life aspects, safety, and tolerability. Results: Thirty-four subjects completed the treatment and study period; one was lost to follow up. Daily use of the evaluated cleanser and moisturizer significantly improved skin condition when comparing day 0 versus day 28 (+/- 5 days (end)) results. Both the physicians and subjects using the dry skin classification scale and GAIS scored a significant improvement of the dry skin condition. After treatment subjects reported a significant improvement in the quality of their professional life, self-image, and social life. The products were shown to be safe, comfortable, and well tolerated. Conclusion: The results indicated the cleanser and moisturizer to offer an effective, easy and comfortable option for dry skin conditions. J Drugs Dermatol. 2019;18(1):80-85.
患有皮肤干燥、起皮和/或脱屑症状的受试者，其皮肤的特点是水分和皮肤脂质含量降低，还有其他一些表现。众所周知，每天使用温和的洁面产品和保湿产品可能有助于恢复和维持最佳的皮肤屏障功能。开展了一项针对干性皮肤患者的队列研究，以评估每日使用含有神经酰胺且含有水杨酸的洁面产品和面霜的疗效。方法：从加拿大的四个皮肤科中心招募了35名轻度至中度干性皮肤状况的成年人。经同意，受试者每天接受两次含有神经酰胺且含有水杨酸的洁面产品和面霜的治疗。使用干性皮肤分类量表和整体美学改善量表（GAIS）对医生和受试者评估的皮肤状况进行评分，比较基线（第0天）与第28天（结束时）的情况。受试者还对满意度、产品特性、生活质量方面、安全性和耐受性进行了评分。结果：34名受试者完成了治疗和研究期；1名失访。比较第0天和第28天（结束时±5天）的结果时，每日使用评估的洁面产品和保湿产品可显著改善皮肤状况。使用干性皮肤分类量表和GAIS的医生和受试者均对干性皮肤状况的显著改善进行了评分。治疗后，受试者报告其职业生活、自我形象和社交生活质量有显著改善。结果表明这些产品安全、舒适且耐受性良好。结论：结果表明，该洁面产品和保湿产品为干性皮肤状况提供了一种有效、简便且舒适的选择。《药物皮肤病学杂志》。2019年；18(1):80 - 85。
