Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang, 330063, China.
State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, 410082, China.
Angew Chem Int Ed Engl. 2017 Jun 26;56(27):7916-7919. doi: 10.1002/anie.201702349. Epub 2017 May 29.
The first iron-catalyzed 1,2-difunctionalization of styrenes and conjugated alkenes with silanes and either N or C, using an oxidative radical strategy, is described. Employing FeCl and di-tert-butyl peroxide allows divergent alkene 1,2-difunctionalizations, including 1,2-aminosilylation, 1,2-arylsilylation, and 1,2-alkylsilylation, which rely on a wide range of nucleophiles, namely, amines, amides, indoles, pyrroles, and 1,3-dicarbonyls, thus providing a powerful platform for producing diverse silicon-containing alkanes.
本文描述了首例铁催化的硅烷与苯乙烯和共轭烯烃的 1,2-双官能化反应，采用的是氧化自由基策略。使用 FeCl 和过氧化二叔丁基，可以实现不同的烯烃 1,2-双官能化反应，包括 1,2-氨硅基化、1,2-芳基硅基化和 1,2-烷基硅基化，这些反应依赖于广泛的亲核试剂，如胺、酰胺、吲哚、吡咯和 1,3-二羰基化合物，从而为合成各种含硅烷的化合物提供了一个强大的平台。
