Knorr A M, Laguna C, Stasch J P
Bayer AG, Institute for Pharmacology, Wuppertal, Federal Republic of Germany.
J Hypertens. 1988 Oct;6(10):839-44.
The influence of a 6-week treatment of female Wistar rats with one-kidney, one clip (1-K, 1 C) renal hypertension, with the calcium antagonist nifedipine on plasma volume, red cell Na+ handling and plasma atrial natriuretic peptide immunoreactivity (ANP-IR) was studied. Measurements were performed at 2 and 6 weeks after surgery. In 1-K, 1 C rats plasma volume was increased and red cell Na+ pump activity was reduced only after 2 weeks. Blood pressure, heart weights and plasma ANP were massively increased after both 2 and 6 weeks. 1-K, 1 C-rats treated with nifedipine had normal plasma volume, plasma ANP, and red cell Na+ pump activity in comparison with sham-operated rats. Increases in blood pressure and heart weights were attenuated. It is concluded that 1-K, 1 C hypertension in the rat is associated with cardiomegaly, rise in plasma ANP, initial hypervolemia and depression of the membrane Na+ pump. Nifedipine prevents the occurrence of hypervolemia and secondary phenomena such as rises in plasma ANP and cardiomegaly. This may play an important contributory role in the prevention of pathological sequelae.
研究了用钙拮抗剂硝苯地平对单肾单夹（1-K，1-C）肾性高血压的雌性Wistar大鼠进行为期6周的治疗，对血浆容量、红细胞钠处理及血浆心钠素免疫反应性（ANP-IR）的影响。在手术后2周和6周进行测量。在1-K，1-C大鼠中，仅在2周后血浆容量增加，红细胞钠泵活性降低。在2周和6周后，血压、心脏重量和血浆ANP均大幅增加。与假手术大鼠相比，用硝苯地平治疗的1-K，1-C大鼠血浆容量、血浆ANP和红细胞钠泵活性正常。血压和心脏重量的增加得到缓解。结论是，大鼠的1-K，1-C高血压与心脏肥大、血浆ANP升高、初始血容量过多及膜钠泵抑制有关。硝苯地平可防止血容量过多及诸如血浆ANP升高和心脏肥大等继发现象的发生。这可能在预防病理后遗症中起重要作用。
