Frank Wolf Maya, Peleg David, Stahl-Rosenzweig Talia, Kurzweil Yaffa, Yogev Yariv
a Department of Obstetrics & Gynecology , Galilee Medical Center, Ziv Medical Center, Faculty of Medicine in Galilee, Bar-Ilan University , Zefat , Israel.
b Department of Obstetrics and Gynecology , Ziv Medical Center, Faculty of Medicine in Galilee, Bar-Ilan University , Zefat , Israel.
Gynecol Endocrinol. 2017 Nov;33(11):849-852. doi: 10.1080/09513590.2017.1323857. Epub 2017 May 10.
We evaluated implications of testing for gestational diabetes mellitus (GDM) in pregnancies complicated by third trimester isolated polyhydramnios with previous negative diabetes screening test. In this retrospective cohort study of 104 pregnant women with polyhydramnios between 2005 and 2013, all had normal first trimester fasting glucose and normal glucose challenge test (GCT < 140 mg/dL). Late onset GDM was diagnosed in five women (4.8%) with isolated polyhydramnios, one abnormal value in the oral glucose tolerance test (OGTT) was identified in four additional women (3.8%). No significant differences were found in risk factors for GDM, mean second trimester GCT (117.5 vs. 107.2 mg/dL, p = 0.38) or fasting glucose values (82 vs. 86 mg/dL, p = 0.29) between women in the polyhydramnios group with and without late GDM diagnosis. Moreover, no significant difference was found in relation to the mode of delivery or birth weight between the studied groups (3437 ± 611 vs. 3331 ± 515 g, p = 0.63). Diagnosis of third trimester polyhydramnios was not associated with increased risk for GDM or neonatal complications.
我们评估了在既往糖尿病筛查试验为阴性、妊娠晚期合并单纯羊水过多的孕妇中进行妊娠期糖尿病（GDM）检测的意义。在这项对2005年至2013年间104例羊水过多孕妇的回顾性队列研究中，所有孕妇孕早期空腹血糖均正常，葡萄糖耐量试验（GCT＜140mg/dL）也正常。5例（4.8%）单纯羊水过多的孕妇被诊断为晚发型GDM，另有4例（3.8%）孕妇口服葡萄糖耐量试验（OGTT）出现1项异常值。在羊水过多组中，诊断为晚发型GDM和未诊断为晚发型GDM的孕妇之间，GDM危险因素、孕中期平均GCT（117.5 vs. 107.2mg/dL，p = 0.38）或空腹血糖值（82 vs. 86mg/dL，p = 0.29）均无显著差异。此外，研究组之间在分娩方式或出生体重方面也无显著差异（3437±611 vs. 3331±515g，p = 0.63）。妊娠晚期羊水过多的诊断与GDM风险增加或新生儿并发症无关。
