Department of Obstetrics and Gynecology, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, P.R. China.
Mol Med Rep. 2020 Aug;22(2):1498-1506. doi: 10.3892/mmr.2020.11225. Epub 2020 Jun 12.
Pregnant women with gestational diabetes mellitus (GDM) may have adverse pregnancy outcomes, even if their blood glucose level is well‑controlled. Aquaporin 3 (AQP3) and adiponectin (APN) serve important roles in fetal growth and development. However, the associations of AQP3 and APN with GDM and pregnancy outcome are not known. Therefore, the present study was performed to evaluate the expression of AQP3 in the placenta and APN in the umbilical artery blood, and the association of the two factors with GDM and pregnancy outcome. The patient cohort was divided into two groups: Pregnant women with GDM; and pregnant women with normal glucose tolerance (NGT). The expression levels of AQP3 in the placenta and APN in the umbilical artery blood were detected. Logistic regression was used to analyze the associations of AQP3 and APN with GDM and pregnancy outcome. The expression levels of AQP3 and AQP3 mRNA in the placenta of the GDM group were decreased compared with that of the NGT group, and the difference was statistically significant (P<0.05). The expression of APN in the umbilical artery blood of the GDM group was also decreased compared with that of the NGT group, and the difference was also statistically significant (P<0.05). Multivariate logistic regression analyses indicated that the AQP3 and APN levels were negatively correlated not only with the risk of developing GDM [AQP3 odds ratio (OR)=5.00 (P<0.01); APN OR=2.98 (P=0.01)], but also with abnormal pregnancy outcome [(AQP3 OR=4.64 (P<0.01); APN OR=5.41 (P<0.01)]. The levels of AQP3 in the placenta and APN in the umbilical cord blood were associated with GDM, and the risk of GDM was increased in pregnant women with decreased AQP3 and APN levels. The AQP3 and APN levels also had an effect on pregnancy outcome. The risk of abnormal pregnancy outcomes, including cesarean section, macrosomia, fetal distress and neonatal asphyxia, was increased in pregnant women with decreased AQP3 and APN levels.
患有妊娠糖尿病（GDM）的孕妇可能会出现不良妊娠结局，即使其血糖水平得到良好控制。水通道蛋白 3（AQP3）和脂联素（APN）在胎儿生长发育中发挥重要作用。然而，AQP3 和 APN 与 GDM 和妊娠结局的关系尚不清楚。因此，本研究旨在评估 AQP3 在胎盘和 APN 在脐动脉血中的表达，并探讨这两种因素与 GDM 和妊娠结局的关系。将患者队列分为两组：GDM 孕妇组和糖耐量正常（NGT）孕妇组。检测胎盘 AQP3 表达水平和脐动脉血 APN 表达水平。采用 logistic 回归分析 AQP3 和 APN 与 GDM 和妊娠结局的关系。GDM 组胎盘 AQP3 及其 mRNA 表达水平低于 NGT 组，差异有统计学意义（P<0.05）。GDM 组脐动脉血 APN 表达水平也低于 NGT 组，差异有统计学意义（P<0.05）。多因素 logistic 回归分析表明，AQP3 和 APN 水平不仅与 GDM 发生风险呈负相关（AQP3 比值比[OR]=5.00，P<0.01；APN OR=2.98，P=0.01），还与异常妊娠结局呈负相关（AQP3 OR=4.64，P<0.01；APN OR=5.41，P<0.01）。胎盘 AQP3 和脐动脉血 APN 水平与 GDM 相关，AQP3 和 APN 水平降低的孕妇 GDM 风险增加。AQP3 和 APN 水平还会影响妊娠结局，AQP3 和 APN 水平降低的孕妇剖宫产、巨大儿、胎儿窘迫和新生儿窒息等不良妊娠结局的风险增加。
