Galindo Inmaculada, Alonso Covadonga
Dpto. de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra. de la Coruña km 7.5, 28040 Madrid, Spain.
Viruses. 2017 May 10;9(5):103. doi: 10.3390/v9050103.
African swine fever (ASF) is a highly contagious viral disease of swine which causes high mortality, approaching 100%, in domestic pigs. ASF is caused by a large, double stranded DNA virus, ASF virus (ASFV), which replicates predominantly in the cytoplasm of macrophages and is the only member of the family, genus . The natural hosts of this virus include wild suids and arthropod vectors of the genus. The infection of ASFV in its reservoir hosts is usually asymptomatic and develops a persistent infection. In contrast, infection of domestic pigs leads to a lethal hemorrhagic fever for which there is no effective vaccine. Identification of ASFV genes involved in virulence and the characterization of mechanisms used by the virus to evade the immune response of the host are recognized as critical steps in the development of a vaccine. Moreover, the interplay of the viral products with host pathways, which are relevant for virus replication, provides the basic information needed for the identification of potential targets for the development of intervention strategies against this disease.
非洲猪瘟（ASF）是一种猪的高度传染性病毒性疾病，在家猪中可导致接近100%的高死亡率。ASF由一种大型双链DNA病毒——非洲猪瘟病毒（ASFV）引起，该病毒主要在巨噬细胞的细胞质中复制，是 科 属的唯一成员。这种病毒的自然宿主包括野猪和 属的节肢动物媒介。ASFV在其储存宿主中的感染通常无症状，并发展为持续性感染。相比之下，家猪感染会导致致命的出血热，目前尚无有效的疫苗。鉴定与毒力相关的ASFV基因以及表征病毒用于逃避宿主免疫反应的机制被认为是开发疫苗的关键步骤。此外，病毒产物与宿主途径（与病毒复制相关）之间的相互作用，为识别针对该疾病开发干预策略的潜在靶点提供了所需的基本信息。
