Almeida Ricardo Vitor Silva de, Pacheco Adhemar Monteiro, Silva Rodrigo Altenfelder, Moricz André de, Campos Tércio de
Discipline of Surgery of the Pancreas and Biliary System, Department of Surgery, Brotherhood of Santa Casa de São Paulo, São Paulo, SP, Brasil.
Arq Bras Cir Dig. 2017 Jan-Mar;30(1):42-46. doi: 10.1590/0102-6720201700010012.
Pancreatic adenocarcinoma remains one of the worst digestive cancers. Surgical resection is the main target when treating a patient with curative intent.
To assess angiolymphatic invasion as a prognostic factor in resected pN0 pancreatic cancer.
Thirty-eight patients were submitted to pancreatoduodenectomy due to head pancreatic cancer. Tumor size, margins, lymph nodes, pTNM staging, angiolymphatic and perineural invasion were described in the pathologists' reports.
Most patients were female. Overall median survival was 13 months. Gemcitabine was the regimen of choice for chemotherapy in selected patients; however, it did not improve overall survival. pR0 resection had better survival compared with pR1. Within the pN0 group, survival was significantly better in patients without angiolymphatic invasion.
Angiolymphatic invasion in N0 pancreatoduodenectomy can be demonstrated by the Hematoxylin-Eosin stain and may predict a poor prognosis factor for those patients.
胰腺腺癌仍然是最恶性的消化系统癌症之一。手术切除是对有治愈意向的患者进行治疗时的主要目标。
评估血管淋巴管侵犯作为切除的pN0胰腺癌的预后因素。
38例因胰头癌接受胰十二指肠切除术的患者。病理报告中描述了肿瘤大小、切缘、淋巴结、pTNM分期、血管淋巴管和神经周围侵犯情况。
大多数患者为女性。总体中位生存期为13个月。吉西他滨是部分患者化疗的首选方案；然而，它并未改善总体生存期。与pR1切除相比，pR0切除的生存期更好。在pN0组中，无血管淋巴管侵犯的患者生存期明显更好。
苏木精-伊红染色可显示N0胰十二指肠切除术中的血管淋巴管侵犯，这可能是这些患者预后不良的一个因素。
