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一个抗原特异性T细胞克隆表达两种不同的T细胞受体α/β异二聚体。

Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone.

作者信息

Matis L A, Ezquerra A, Coligan J E

机构信息

Division of Biochemistry and Biophysics, Food and Drug Administration, Bethesda, Maryland.

出版信息

J Exp Med. 1988 Dec 1;168(6):2379-84. doi: 10.1084/jem.168.6.2379.

DOI:10.1084/jem.168.6.2379
PMID:2848922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189151/
Abstract

A cytochrome c-specific, MHC-restricted T cell clone with two complete rearrangements of the same V beta 1 gene element was shown to express two different TCR alpha/beta heterodimers. Antipeptide antisera specific for TCR C beta 1 and C beta 2 peptides each immunoprecipitated distinct disulfide-linked cell surface heterodimers. The clone was derived from immunized allogeneic chimeric mice, and displayed multiple Ia specificities, including the ability to recognize antigen in association with both I-Ek and I-Es Ia molecules, as well as alloreactivity to the I-Eb molecule. It will be important to determine whether each receptor contributes independently to the overall specificity of the clone.

摘要

一个细胞色素c特异性、MHC限制的T细胞克隆，其相同的Vβ1基因元件有两次完整重排，被证明表达两种不同的TCRα/β异二聚体。针对TCR Cβ1和Cβ2肽的抗肽抗血清分别免疫沉淀出不同的二硫键连接的细胞表面异二聚体。该克隆源自免疫的同种异体嵌合小鼠，表现出多种Ia特异性，包括识别与I-Ek和I-Es Ia分子相关的抗原的能力，以及对I-Eb分子的同种异体反应性。确定每个受体是否独立地对克隆的整体特异性起作用将很重要。

相似文献

1
Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone.一个抗原特异性T细胞克隆表达两种不同的T细胞受体α/β异二聚体。
J Exp Med. 1988 Dec 1;168(6):2379-84. doi: 10.1084/jem.168.6.2379.
2
The molecular basis of alloreactivity in antigen-specific, major histocompatibility complex-restricted T cell clones.抗原特异性、主要组织相容性复合体限制的T细胞克隆中同种异体反应性的分子基础。
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3
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Analysis of peptide binding patterns in different major histocompatibility complex/T cell receptor complexes using pigeon cytochrome c-specific T cell hybridomas. Evidence that a single peptide binds major histocompatibility complex in different conformations.利用鸽细胞色素c特异性T细胞杂交瘤分析不同主要组织相容性复合体/T细胞受体复合物中的肽结合模式。单一肽以不同构象结合主要组织相容性复合体的证据。
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本文引用的文献

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Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression.异常重排对免疫球蛋白基因表达的等位基因排斥有显著贡献。
Nature. 1981 Apr 2;290(5805):372-8. doi: 10.1038/290372a0.
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Bone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytes.骨髓来源的胸腺抗原呈递细胞决定了Ia限制型T淋巴细胞的自身识别。
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The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition.T细胞抗原受体的分子遗传学与T细胞抗原识别
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Alternative protein products with different carboxyl termini from a single class I gene, H-2Kb.来自单个 I 类基因 H-2Kb 的具有不同羧基末端的替代蛋白产物。
Proc Natl Acad Sci U S A. 1986 Aug;83(16):6084-8. doi: 10.1073/pnas.83.16.6084.
5
In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes.在转基因小鼠中，导入的功能性T细胞受体β基因会阻止内源性β基因的表达。
Cell. 1988 Mar 25;52(6):831-41. doi: 10.1016/0092-8674(88)90425-4.
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T cell receptor gamma/delta chain diversity.T细胞受体γ/δ链多样性
J Exp Med. 1988 Feb 1;167(2):676-81. doi: 10.1084/jem.167.2.676.
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Rearrangement and transcription of the beta-chain genes of the T-cell antigen receptor in different types of murine lymphocytes.不同类型鼠淋巴细胞中T细胞抗原受体β链基因的重排与转录
Nature. 1985;313(6004):647-53. doi: 10.1038/313647a0.
8
Genomic organization of the mouse T-cell receptor beta-chain gene family.小鼠T细胞受体β链基因家族的基因组组织
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3846-50. doi: 10.1073/pnas.84.11.3846.
9
Generation of diversity in T cell receptor repertoire specific for pigeon cytochrome c.针对鸽细胞色素c的T细胞受体库多样性的产生。
J Exp Med. 1987 Feb 1;165(2):279-301. doi: 10.1084/jem.165.2.279.
10
Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c.小鼠细胞色素c的T细胞受体中Vα基因片段的主要使用情况。
Nature. 1986;324(6098):679-82. doi: 10.1038/324679a0.