T细胞受体γ/δ链多样性
T cell receptor gamma/delta chain diversity.
作者信息
Koning F, Kruisbeek A M, Maloy W L, Marusic-Galesic S, Pardoll D M, Shevach E M, Stingl G, Valas R, Yokoyama W M, Coligan J E
机构信息
Biological Resources Branch, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
出版信息
J Exp Med. 1988 Feb 1;167(2):676-81. doi: 10.1084/jem.167.2.676.
The TCR-gamma and -delta chains of six murine hybridomas were compared by one-dimensional SDS-PAGE and two-dimensional NEPHGE/SDS-PAGE analysis. This allowed the identification of three distinct gamma chains (gamma a, gamma b, and gamma c) and three distinct delta chains (delta a, delta b, and delta c). Four gamma/delta chain combinations (gamma a delta a, gamma b delta b, gamma b delta c, and gamma c delta a) were observed. These results indicate that multiple forms of the delta chain are expressed and suggest that the delta chains are encoded for by an Ig-like rearranging gene. This delta chain polymorphism significantly enhances the potential diversity of TCR-gamma/delta, which may be of importance for a better understanding of the putative ligand(s) recognized by this receptor.
通过一维SDS-PAGE和二维NEPHGE/SDS-PAGE分析比较了六种小鼠杂交瘤的TCR-γ和-δ链。这使得能够鉴定出三种不同的γ链（γa、γb和γc）和三种不同的δ链（δa、δb和δc）。观察到四种γ/δ链组合（γaδa、γbδb、γbδc和γcδa）。这些结果表明δ链有多种形式表达，并提示δ链由一个Ig样重排基因编码。这种δ链多态性显著增强了TCR-γ/δ的潜在多样性，这对于更好地理解该受体识别的假定配体可能具有重要意义。
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