异常重排对免疫球蛋白基因表达的等位基因排斥有显著贡献。
Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression.
作者信息
Coleclough C, Perry R P, Karjalainen K, Weigert M
出版信息
Nature. 1981 Apr 2;290(5805):372-8. doi: 10.1038/290372a0.
DOI:10.1038/290372a0
PMID:6783959
Abstract
A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.
摘要
一项对小鼠脾脏B细胞、脾脏来源的杂交瘤和浆细胞瘤中轻链和重链免疫球蛋白基因组织的研究明确表明，在正常B细胞发育过程中，异常重排很常见。这些结果支持了免疫球蛋白基因表达等位基因排斥的概率模型。
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