Williams J H
Department of Companion Animal Medicine and Surgery, Faculty of Veterinary Science, Republic of South Africa.
J S Afr Vet Assoc. 1988 Sep;59(3):141-4.
The use of Gamma linolenic acid (GLA) and other essential fatty acid (EFA) metabolites in malignant cancer treatment in vitro and in vivo is briefly reviewed. Treatment of two dogs with multicentric lymphoma with large empirical daily doses of a combination of 40 mg gamma linolenic acid, 350 mg linoleic acid and 10 mg natural vitamin E per capsule resulted, after approximately one week, in slight to marked reduction in size of enlarged peripheral lymph nodes, spleen, skin nodules and tonsils. Both animals showed transient improved habitus and appetite, but deteriorated due to complications, apparently unrelated to therapy.
本文简要综述了γ-亚麻酸（GLA）和其他必需脂肪酸（EFA）代谢产物在体外和体内恶性肿瘤治疗中的应用。用每粒含40毫克γ-亚麻酸、350毫克亚油酸和10毫克天然维生素E的组合药物，以大剂量经验性每日给药治疗两只患有多中心淋巴瘤的犬，大约一周后，肿大的外周淋巴结、脾脏、皮肤结节和扁桃体大小出现轻微至显著缩小。两只动物的身体状况和食欲都有短暂改善，但由于并发症（显然与治疗无关）而恶化。
