1Children's Health and Exercise Research Centre, Sport and Health Sciences, University of Exeter, Exeter, UNITED KINGDOM; and 2Royal Devon and Exeter NHS Foundation Trust Hospital, Exeter, UNITED KINGDOM.
Med Sci Sports Exerc. 2017 Oct;49(10):1980-1986. doi: 10.1249/MSS.0000000000001314.
The aim of this study was to describe the relationship between body size and oxygen uptake efficiency slope (OUES) in pediatric patients with cystic fibrosis (CF) and healthy controls (CON), to identify appropriate scaling procedures to adjust the influence of body size upon OUES.
The OUES was derived using maximal and submaximal points from cardiopulmonary exercise testing in 72 children (36 CF and 36 CON). OUES was subsequently scaled for stature, body mass (BM), and body surface area (BSA) using ratio-standard (Y/X) and allometric (Y/X) methods. Pearson's correlation coefficients were used to determine the relationship between body size and OUES.
When scaled using the ratio-standard method, OUES had a significant positive relationship with stature (r = 0.54, P < 0.001) and BSA (r = 0.25, P = 0.031) and significant negative relationship with BM (r = -0.38, P = 0.016) in the CF group. Combined allometric exponents (b) for CF and CON were stature 3.00, BM 0.86, and BSA 1.40. A significant negative correlation was found between OUES and stature in the CF group when scaled allometrically (r = -0.37, P = 0.027). Nonsignificant (P > 0.05) correlations for the whole group were found between OUES and allometrically scaled BM (CF r = -0.25, CON, r = 0.15) and BSA (CF r = -0.27, CON r = 0.13).
Only allometric scaling of either BM or BSA, and not ratio-standard scaling, successfully eliminates the influence of body size upon OUES. Therefore, this enables a more direct comparison of the OUES between patients with CF and healthy controls.
本研究旨在描述囊性纤维化（CF）患儿和健康对照（CON）的体型与摄氧量效率斜率（OUES）之间的关系，确定适当的标度方法以调整体型对 OUES 的影响。
在 72 名儿童（36 名 CF 和 36 名 CON）的心肺运动测试中，从最大和次最大点得出 OUES。随后使用比率标准（Y/X）和比例（Y/X）方法对身高、体重（BM）和体表面积（BSA）进行 OUES 标度。使用 Pearson 相关系数确定体型与 OUES 之间的关系。
当使用比率标准方法进行标度时，CF 组 OUES 与身高（r = 0.54，P < 0.001）和 BSA（r = 0.25，P = 0.031）呈显著正相关，与 BM（r = -0.38，P = 0.016）呈显著负相关。CF 和 CON 的综合比例指数（b）分别为身高 3.00、BM 0.86 和 BSA 1.40。当 CF 组的 OUES 按比例标度时，发现与身高呈显著负相关（r = -0.37，P = 0.027）。全组 OUES 与比例标度的 BM（CF r = -0.25，CON r = 0.15）和 BSA（CF r = -0.27，CON r = 0.13）之间存在无显著相关性（P > 0.05）。
仅 BM 或 BSA 的比例标度，而不是比率标准标度，成功消除了体型对 OUES 的影响。因此，这可以更直接地比较 CF 患者和健康对照者的 OUES。
