Giraldi Luca, Michelazzo Maria B, Arzani Dario, Persiani Roberto, Pastorino Roberta, Boccia Stefania
Section of Hygiene, Institute of Public Health, Universitá Cattolica del Sacro Cuore.
General Surgery Unit, Department of Surgery.
Eur J Cancer Prev. 2018 Jul;27(4):323-330. doi: 10.1097/CEJ.0000000000000348.
The risk of Helicobacter pylori (HP) infection, as well as gastric cancer (GC), in association with genetic polymorphisms of gene encoding for mucins, has been investigated with contradictory results. We carried out this systematic review and meta-analysis to summarize the relationship between MUC1, MUC5AC, and MUC6 polymorphisms and HP infection, as well as GC risk. We searched MEDLINE, ISI Web of Science, Scopus bibliographic databases and the HuGE Navigator database. Odds ratios (ORs) and 95% confidence interval (CI) were calculated to assess the association between the genetic polymorphisms, and HP/GC risk. A random-effect model was used to calculate the pooled ORs, overall and by ethnicity. Twenty-one studies were included, of which five on HP and 18 on GC, of which two were in common. The meta-analysis of 10 studies on the MUC1 rs4072037 polymorphism and GC risk reported an OR of 0.66 (95% CI: 0.57-0.78) for the dominant model (AG/GG vs. AA). When stratifying for ethnicity, an OR of 0.73 (95% CI: 0.62-0.86) was reported for the Asian population and an OR of 0.48 (95% CI: 0.38-0.61) was reported for the White population. Our study confirms the protective effect of MUC1 rs4072037 polymorphism on the risk of GC under the dominant model. Further studies reporting information on HP status in cases and controls would be required to evaluate whether the protective effect of MUC1 protein might be attributable to a protective effect towards the HP infection, or through different mechanisms.
幽门螺杆菌（HP）感染风险以及胃癌（GC）与黏蛋白编码基因的基因多态性之间的关系已得到研究，但结果相互矛盾。我们进行了这项系统评价和荟萃分析，以总结MUC1、MUC5AC和MUC6基因多态性与HP感染以及GC风险之间的关系。我们检索了MEDLINE、ISI科学网、Scopus文献数据库和HuGE导航数据库。计算比值比（OR）和95%置信区间（CI）以评估基因多态性与HP/GC风险之间的关联。采用随机效应模型计算总体及按种族分类的合并OR。纳入了21项研究，其中5项关于HP，18项关于GC，其中2项是共同的。对10项关于MUC1 rs4072037基因多态性与GC风险的研究进行的荟萃分析报告，显性模型（AG/GG与AA）的OR为0.66（95%CI：0.57 - 0.78）。按种族分层时，亚洲人群的OR为0.73（95%CI：0.62 - 0.86），白人人群的OR为0.48（95%CI：0.38 - 0.61）。我们的研究证实了MUC1 rs4072037基因多态性在显性模型下对GC风险的保护作用。需要进一步的研究报告病例和对照中HP状态的信息，以评估MUC1蛋白的保护作用是否可归因于对HP感染的保护作用，或通过不同机制。
