周细胞的可塑性如何？
How Plastic Are Pericytes?
作者信息
Birbrair Alexander, Borges Isabella da Terra, Gilson Sena Isadora Fernandes, Almeida Gregório Guilherme, da Silva Meirelles Lindolfo, Gonçalves Ricardo, Mintz Akiva, Delbono Osvaldo
机构信息
1 Department of Pathology, Federal University of Minas Gerais , Belo Horizonte, MG, Brazil .
2 Department of Cell Biology, Albert Einstein College of Medicine , Bronx, New York.
出版信息
Stem Cells Dev. 2017 Jul 15;26(14):1013-1019. doi: 10.1089/scd.2017.0044. Epub 2017 Jun 13.
Abstract
Pericytes are defined by both their anatomical location and molecular markers. Numerous publications have reported their role as stem cells, contributing to the formation of tissues other than blood vessels. However, using cell-lineage tracing in a new transgenic mouse model, a recent study shows that in the context of aging and some pathologies, Tbx18+ pericytes do not function as stem cells in vivo. This study challenges the current view that pericytes can differentiate into other cells and reopen questions about their plasticity. This emerging knowledge is important not only for our understanding of development but may also inform treatments for diseases.
摘要
周细胞是由其解剖位置和分子标记物共同定义的。众多出版物报道了它们作为干细胞的作用，参与除血管以外的其他组织的形成。然而，最近一项研究在一种新的转基因小鼠模型中使用细胞谱系追踪技术表明，在衰老和某些病理情况下，Tbx18 +周细胞在体内并不发挥干细胞的功能。这项研究对周细胞可分化为其他细胞的当前观点提出了挑战，并重新引发了关于其可塑性的问题。这一新兴知识不仅对我们理解发育过程很重要，也可能为疾病治疗提供思路。
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