Wu Li, Xie Yutao
Department of Infectious Disease, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Apr 28;42(4):463-467. doi: 10.11817/j.issn.1672-7347.2017.04.016.
With the economic growth and better standards of living, the prevalence of non-alcoholic fatty liver disease (NAFLD) is expected to increase dramatically worldwide. NAFLD is a common chronic inflammation disease. NF-κB is a transcription factor that plays crucial roles in inflammation, immunity, cell proliferation and apoptosis. It can facilitate the occurrence and development of NAFLD, and the underlying mechanisms are related to insulin resistance, oxidative stress, alteration of intestinal flora, activation of renin angiotensin system, etc.
随着经济增长和生活水平提高，预计非酒精性脂肪性肝病（NAFLD）在全球的患病率将急剧上升。NAFLD是一种常见的慢性炎症性疾病。核因子κB（NF-κB）是一种转录因子，在炎症、免疫、细胞增殖和凋亡中起关键作用。它可促进NAFLD的发生和发展，其潜在机制与胰岛素抵抗、氧化应激、肠道菌群改变、肾素血管紧张素系统激活等有关。
