Department of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, No. 56, Xinjian South Road, Taiyuan, Shanxi 030001, China.
Oxid Med Cell Longev. 2017;2017:3256241. doi: 10.1155/2017/3256241. Epub 2017 Sep 7.
The prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically increased globally during recent decades. Intake of n-3 polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3), is believed to be beneficial to the development of NAFLD. However, little information is available with regard to the effect of flaxseed oil rich in -linolenic acid (ALA, C18:3n-3), a plant-derived n-3 PUFA, in improving NAFLD. This study was to gain the effect of flaxseed oil on NAFLD and further investigate the underlying mechanisms. Apolipoprotein-E knockout (apoE-KO) mice were given a normal chow diet, a western-type high-fat and high-cholesterol diet (WTD), or a WTD diet containing 10% flaxseed oil (WTD + FO) for 12 weeks. Our data showed that consumption of flaxseed oil significantly improved WTD-induced NAFLD, as well as ameliorated impaired lipid homeostasis, attenuated oxidative stress, and inhibited inflammation. These data were associated with the modification effects on expression levels of genes involved in de novo fat synthesis (SREBP-1c, ACC), triacylglycerol catabolism (PPAR, CPT1A, and ACOX1), inflammation (NF-B, IL-6, TNF-, and MCP-1), and oxidative stress (ROS, MDA, GSH, and SOD).
在最近几十年中，非酒精性脂肪性肝病（NAFLD）的患病率在全球范围内显著增加。摄入 n-3 多不饱和脂肪酸（PUFAs），主要是二十碳五烯酸（EPA，C20:5n-3）和二十二碳六烯酸（DHA，C22:6n-3），被认为对 NAFLD 的发展有益。然而，关于富含亚麻酸（ALA，C18:3n-3）的亚麻籽油对改善 NAFLD 的影响，信息很少。本研究旨在探讨亚麻籽油对 NAFLD 的影响，并进一步研究其潜在机制。载脂蛋白-E 敲除（apoE-KO）小鼠给予正常饮食、西式高脂肪高胆固醇饮食（WTD）或含 10％亚麻籽油的 WTD 饮食（WTD+FO）12 周。我们的数据表明，摄入亚麻籽油可显著改善 WTD 诱导的 NAFLD，并改善脂质代谢紊乱，减轻氧化应激，抑制炎症。这些数据与参与从头脂肪合成（SREBP-1c、ACC）、甘油三酯分解代谢（PPAR、CPT1A 和 ACOX1）、炎症（NF-B、IL-6、TNF-α和 MCP-1）和氧化应激（ROS、MDA、GSH 和 SOD）的基因表达水平的修饰作用有关。
