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使用因子分析识别功能互联的神经元

Identification of Functionally Interconnected Neurons Using Factor Analysis.

作者信息

Soletta Jorge H, Farfán Fernando D, Albarracín Ana L, Pizá Alvaro G, Lucianna Facundo A, Felice Carmelo J

机构信息

Laboratorio de Medios e Interfases, Departamento de Bioingeniería (DBI), Facultad de Ciencias Exactas y Tecnología (FACET), Universidad Nacional de Tucumán (UNT), San Miguel de Tucumán, Argentina.

Instituto Superior de Investigaciones Biológicas (INSIBIO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Miguel de Tucumán, Argentina.

出版信息

Comput Intell Neurosci. 2017;2017:8056141. doi: 10.1155/2017/8056141. Epub 2017 Apr 16.

Abstract

The advances in electrophysiological methods have allowed registering the joint activity of single neurons. Thus, studies on functional dynamics of complex-valued neural networks and its information processing mechanism have been conducted. Particularly, the methods for identifying neuronal interconnections are in increasing demand in the area of neurosciences. Here, we proposed a factor analysis to identify functional interconnections among neurons via spike trains. This method was evaluated using simulations of neural discharges from different interconnections schemes. The results have revealed that the proposed method not only allows detecting neural interconnections but will also allow detecting the presence of presynaptic neurons without the need of the recording of them.

摘要

电生理方法的进步使得记录单个神经元的联合活动成为可能。因此,已经开展了关于复值神经网络功能动力学及其信息处理机制的研究。特别是,在神经科学领域,识别神经元互连的方法需求日益增加。在此,我们提出了一种因子分析方法,通过尖峰序列来识别神经元之间的功能互连。该方法通过对不同互连方案的神经放电进行模拟来评估。结果表明,所提出的方法不仅能够检测神经互连,还能够在无需记录突触前神经元的情况下检测其存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25da/5410375/1bd706655aad/CIN2017-8056141.001.jpg

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