Carr Susan V, Martin Patricia A, Keyes Samantha L, Tong Lydia J, Talbot Jessica J, Muscatello Gary, Barrs Vanessa R
Faculty of Veterinary Science, University of Sydney, NSW, Australia.
JFMS Open Rep. 2015 Jul 29;1(2):2055116915597240. doi: 10.1177/2055116915597240. eCollection 2015 Jul-Dec.
A 2-year-old female spayed domestic shorthair cat was presented for a progressive subcutaneous nasofacial swelling. Histology of biopsy tissue revealed pyogranulomatous inflammation and large numbers of gram-negative capsulated bacterial coccobacilli within macrophages. The isolate was fastidious and grew after 6 days under microaerophilic conditions in a candle jar. The molecular identity of the isolate, from comparative sequence analysis of the 16s rRNA gene, is an as yet to be classified bacterial species within a novel genus of . Infection resolved after 7 months of antimicrobial therapy with doxycycline and trimethoprim sulfamethoxazole. There has been no further recurrence of clinical signs in a 3 year follow-up period.
Cats are susceptible to nasofacial infections as a result of traumatic inoculation of environmental bacteria, fungi and protozoa. We report a novel pathogen in the family, identified by 16 sRNA comparative sequence analysis, as a cause of nasofacial infection in a cat, and its subsequent successful treatment with combination antimicrobial therapy.
一只2岁已绝育的雌性家养短毛猫因进行性皮下鼻面部肿胀前来就诊。活检组织的组织学检查显示为脓性肉芽肿性炎症，巨噬细胞内有大量革兰氏阴性包膜菌球杆菌。该分离株苛求，在烛缸微需氧条件下6天后生长。通过对16s rRNA基因的比较序列分析，该分离株的分子鉴定结果是一个尚未分类的细菌物种，属于一个新属。用强力霉素和甲氧苄啶磺胺甲恶唑进行7个月的抗菌治疗后感染得到解决。在3年的随访期内临床症状未再复发。
由于环境细菌、真菌和原生动物的创伤性接种，猫易患鼻面部感染。我们报告了一种新的病原体，通过16 sRNA比较序列分析鉴定为猫鼻面部感染的病因，并随后通过联合抗菌治疗成功治愈。
