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High-dose loperamide abuse-associated ventricular arrhythmias.

作者信息

O'Connell Charles W, Schricker Amir A, Schneir Aaron B, Metushi Imir G, Birgersdotter-Green Ulrika, Minns Alicia B

机构信息

Division of Medical Toxicology, Department of Emergency Medicine, University of California - San Diego, San Diego, California.

Department of Emergency Medicine, Veterans Association San Diego, La Jolla, California.

出版信息

HeartRhythm Case Rep. 2016 Mar 7;2(3):232-236. doi: 10.1016/j.hrcr.2016.01.002. eCollection 2016 May.

DOI:10.1016/j.hrcr.2016.01.002
PMID:28491676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5419750/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31ac/5419750/ddf7834e3ead/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31ac/5419750/11d00078947d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31ac/5419750/a3ba3e280b7c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31ac/5419750/f583f0ace7e5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31ac/5419750/7c3cf89a24e2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31ac/5419750/ddf7834e3ead/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31ac/5419750/11d00078947d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31ac/5419750/a3ba3e280b7c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31ac/5419750/f583f0ace7e5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31ac/5419750/7c3cf89a24e2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31ac/5419750/ddf7834e3ead/gr5.jpg

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引用本文的文献

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本文引用的文献

1
Loperamide toxicokinetics: serum concentrations in the overdose setting.洛哌丁胺的毒代动力学：过量用药情况下的血清浓度
Clin Toxicol (Phila). 2015 Jun;53(5):495-6. doi: 10.3109/15563650.2015.1026971. Epub 2015 Mar 30.
2
Cardiac conduction disturbance after loperamide abuse.滥用洛哌丁胺后出现心脏传导障碍。
Clin Toxicol (Phila). 2014 Nov;52(9):952-7. doi: 10.3109/15563650.2014.969371.
3
"I just wanted to tell you that loperamide WILL WORK": a web-based study of extra-medical use of loperamide.“我只是想告诉你，洛哌丁胺是有效的”：一项关于洛哌丁胺非医疗用途的网络研究。
Drug Saf Case Rep. 2018 Feb 17;5(1):11. doi: 10.1007/s40800-018-0077-0.
4
Loperamide cardiotoxicity: "A Brief Review".洛哌丁胺的心脏毒性：“简要综述”
Ann Noninvasive Electrocardiol. 2018 Mar;23(2):e12505. doi: 10.1111/anec.12505. Epub 2017 Nov 10.
Drug Alcohol Depend. 2013 Jun 1;130(1-3):241-4. doi: 10.1016/j.drugalcdep.2012.11.003. Epub 2012 Nov 30.
4
Insights for human ether-a-go-go-related gene potassium channel inhibition using recursive partitioning and Kohonen and Sammon mapping techniques.使用递归划分以及Kohonen和Sammon映射技术对人类醚-去极化相关基因钾通道抑制的见解。
J Med Chem. 2006 Aug 24;49(17):5059-71. doi: 10.1021/jm060076r.
5
Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes.鉴定参与洛哌丁胺在人肝微粒体中代谢的细胞色素P450同工酶。
Eur J Clin Pharmacol. 2004 Oct;60(8):575-81. doi: 10.1007/s00228-004-0815-3. Epub 2004 Sep 8.
6
Drugs as P-glycoprotein substrates, inhibitors, and inducers.作为P-糖蛋白底物、抑制剂和诱导剂的药物。
Drug Metab Rev. 2002 Feb-May;34(1-2):47-54. doi: 10.1081/dmr-120001389.
7
Inhibition of drug metabolism in human liver microsomes by nizatidine, cimetidine and omeprazole.尼扎替丁、西咪替丁和奥美拉唑对人肝微粒体中药物代谢的抑制作用。
Xenobiotica. 2001 Jan;31(1):1-10. doi: 10.1080/00498250110035615.
8
Long QT syndrome.长QT综合征
Cardiol Clin. 2000 May;18(2):309-25. doi: 10.1016/s0733-8651(05)70143-0.
9
Bioequivalence evaluation of two different oral formulations of loperamide (Diarex Lactab vs Imodium capsules).两种不同口服剂型洛哌丁胺（Diarex Lactab与易蒙停胶囊）的生物等效性评价。
Int J Clin Pharmacol Ther. 1995 Aug;33(8):431-6.
10
Sinus arrest associated with continuous-infusion cimetidine.
Pharmacotherapy. 1993 Jan-Feb;13(1):64-7.