Blindbæk Søren Leer, Torp Thomas Lee, Lundberg Kristian, Soelberg Kerstin, Vergmann Anna Stage, Poulsen Christina Døfler, Frydkjaer-Olsen Ulrik, Broe Rebecca, Rasmussen Malin Lundberg, Wied Jimmi, Lind Majbrit, Vestergaard Anders Højslet, Peto Tunde, Grauslund Jakob
Department of Ophthalmology, Odense University Hospital, Odense, Denmark.
Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
J Diabetes Res. 2017;2017:2562759. doi: 10.1155/2017/2562759. Epub 2017 Apr 13.
The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- and macrovascular dysfunction in diabetes. Likewise, the retinal metabolism can be evaluated by retinal oximetry, and higher retinal venular oxygen saturation has been demonstrated in patients with diabetic retinopathy. So far, most studies have been cross-sectional, but these can only disclose associations and are not able to separate cause from effect or to establish the predictive value of retinal vascular dysfunction with respect to long-term complications. Likewise, retinal markers have not been investigated as markers of treatment outcome in patients with proliferative diabetic retinopathy and diabetic macular edema. The Department of Ophthalmology at Odense University Hospital, Denmark, has a strong tradition of studying the retinal microvasculature in diabetic retinopathy. In the present paper, we demonstrate the importance of the retinal vasculature not only as predictors of long-term microvasculopathy but also as markers of treatment outcome in sight-threatening diabetic retinopathy in well-established population-based cohorts of patients with diabetes.
视网膜血管系统是人体唯一可直接进行体内检查的部分。非侵入性视网膜标志物对于识别有视力威胁性糖尿病视网膜病变风险的患者很重要。研究已将视网膜血管管径和分形等结构特征与糖尿病中的微血管和大血管功能障碍联系起来。同样，视网膜代谢可通过视网膜血氧测定法进行评估，并且在糖尿病视网膜病变患者中已证实视网膜静脉血氧饱和度较高。到目前为止，大多数研究都是横断面研究，但这些研究只能揭示关联，无法区分因果关系，也无法确定视网膜血管功能障碍对长期并发症的预测价值。同样，视网膜标志物尚未作为增殖性糖尿病视网膜病变和糖尿病性黄斑水肿患者治疗结果的标志物进行研究。丹麦欧登塞大学医院眼科有着研究糖尿病视网膜病变中视网膜微血管的悠久传统。在本文中，我们证明了视网膜血管系统不仅作为长期微血管病变的预测指标很重要，而且在已确立的糖尿病患者人群队列中，作为视力威胁性糖尿病视网膜病变治疗结果的标志物也很重要。
