Gao Yuan, Xu Lijun, He Ning, Ding Yuchuan, Zhao Wenbo, Meng Tingting, Li Ming, Wu Jiaqi, Haddad Yazeed, Zhang Xuxiang, Ji Xunming
Department of Biomedical Engineering, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Brain Circ. 2023 Sep 27;9(3):129-134. doi: 10.4103/bc.bc_9_23. eCollection 2023 Jul-Sep.
The retina, as an external extension of the diencephalon, can be directly, noninvasively observed by ocular fundus photography. Therefore, it offers a convenient and feasible mode to study nervous system diseases. Caliber, tortuosity, and fractal dimension, as three commonly used retinal vascular parameters, are not only the reflection of structural changes in the retinal microcirculation but also capture the branching pattern or density changes of the retinal microvascular network. Therefore, it contributes to better reflecting the subclinical pathological changes (e.g., lacunar stroke and small cerebral vascular disease) and predicting the risk of incident stroke and recurrent stroke.
视网膜作为间脑的一个外部延伸部分，可通过眼底照相术直接、无创地进行观察。因此，它为研究神经系统疾病提供了一种方便且可行的方式。管径、迂曲度和分形维数作为三个常用的视网膜血管参数，不仅反映了视网膜微循环的结构变化，还捕捉到了视网膜微血管网络的分支模式或密度变化。因此，它有助于更好地反映亚临床病理变化（如腔隙性卒中及小脑血管疾病），并预测首次卒中和复发性卒中的风险。
