新诊断寻常型天疱疮患者催乳素水平评估及其与天疱疮疾病面积指数的相关性
Evaluation of prolactin levels in patients with newly diagnosed pemphigus vulgaris and its correlation with pemphigus disease area index.
作者信息
Lajevardi Vahideh, Hallaji Zahra, Daneshpazhooh Maryam, Ghandi Narges, Shekari Peyman, Khani Sepideh
机构信息
Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.
Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Int J Womens Dermatol. 2016 Apr 23;2(2):53-55. doi: 10.1016/j.ijwd.2016.02.004. eCollection 2016 Jun.
BACKGROUND
Prolactin is a hormone; in addition to it known roles, it has immunomodulatory effects on lymphocytes maturation and immunoglobulins production. Hyperprolactinemia has been demonstrated in various autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, type I diabetes mellitus, and Graves' disease. In view of the prolactin immunomodulatory roles, studying prolactin levels in pemphigus as an autoimmune blistering disease may introduce new ways of understanding disease etiology and developing treatment strategies.
OBJECTIVE
Our purpose was to determine the prolactin levels in patients with newly diagnosed pemphigus vulgaris and study its correlation with pemphigus disease area index.
LIMITATION
Our study was limited by the lack of a control group.
METHODS
In this cross-sectional study, prolactin and anti-desmoglein 1 and 3 autoantibodies levels were measured in 50 patients with newly diagnosed pemphigus vulgaris in Razi Dermatology Hospital. Pemphigus severity and extent was estimated using the Pemphigus Disease Area Index.
RESULTS
Of the 50 patients, 18 were male and 32 were female with a mean age of 41.56 ± 13.66 years. Mean prolactin (PRL) level was 15.60 ± 11.72 ng/ml (10.68 in males and 18.37 in females). Mean anti-desmoglein 1 and 3 autoantibodies were 135.8 ± 119.8 and 245.8 ± 157.4 U/ml, respectively. Eleven out of 50 patients had a higher than normal prolactin range. No relation was found between prolactin level and disease activity ( = .982). Also, correlation studies show no relation between prolactin and anti-desmoglein 1 and 3 autoantibodies levels (respectively, = .771 and .738). In comparing the extent of the disease between the two groups with normal and high prolactin, paired t-test showed no significance ( = .204).
CONCLUSION
In our study, 22% of patients had hyperprolactinemia, which was greater among females. The highest PRL level was detected in mucocutaneous group. Although serum PRL levels were higher in patients with a greater Pemphigus Disease Area Index, it did not reach statistical significance.
背景
催乳素是一种激素；除了其已知作用外，它对淋巴细胞成熟和免疫球蛋白产生具有免疫调节作用。高催乳素血症已在多种自身免疫性疾病中得到证实，如系统性红斑狼疮、类风湿性关节炎、I型糖尿病和格雷夫斯病。鉴于催乳素的免疫调节作用，研究天疱疮（一种自身免疫性水疱病）患者的催乳素水平可能会为理解疾病病因和制定治疗策略带来新方法。
目的
我们的目的是测定新诊断的寻常型天疱疮患者的催乳素水平，并研究其与天疱疮疾病面积指数的相关性。
局限性
我们的研究因缺乏对照组而受到限制。
方法
在这项横断面研究中，对拉齐皮肤病医院50例新诊断的寻常型天疱疮患者测定了催乳素以及抗桥粒芯糖蛋白1和3自身抗体水平。使用天疱疮疾病面积指数评估天疱疮的严重程度和范围。
结果
50例患者中，18例为男性，32例为女性，平均年龄为41.56±13.66岁。平均催乳素（PRL）水平为15.60±11.72 ng/ml（男性为10.68，女性为18.37）。抗桥粒芯糖蛋白1和3自身抗体的平均水平分别为135.8±119.8和245.8±157.4 U/ml。50例患者中有11例催乳素范围高于正常。未发现催乳素水平与疾病活动度之间存在关联（P = 0.982）。此外，相关性研究表明催乳素与抗桥粒芯糖蛋白1和3自身抗体水平之间无关联（分别为P = 0.771和0.738）。在比较催乳素正常和高的两组患者的疾病范围时，配对t检验无显著性差异（P = 0.204）。
结论
在我们的研究中，22%的患者患有高催乳素血症，女性更为多见。在黏膜皮肤组中检测到最高的PRL水平。尽管天疱疮疾病面积指数较高的患者血清PRL水平也较高，但未达到统计学显著性。
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