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Adv Biomed Res. 2016 Dec 27;5:206. doi: 10.4103/2277-9175.191002. eCollection 2016.
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[Detection of serum desmoglein antibody level using enzyme-linked immunosorbent assay (ELISA) for monitoring disease activity in patients with pemphigus vulgaris].[采用酶联免疫吸附测定法（ELISA）检测血清桥粒芯糖蛋白抗体水平以监测寻常型天疱疮患者的疾病活动度]
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Prolactin: A Mammalian Stress Hormone and Its Role in Cutaneous Pathophysiology.催乳素：一种哺乳动物应激激素及其在皮肤病理生理学中的作用。
Int J Mol Sci. 2024 Jun 28;25(13):7100. doi: 10.3390/ijms25137100.

本文引用的文献

1
Serum prolactin levels in Behçet's disease. Is there a relationship between Behcet's disease and prolactin as in other autoimmune diseases?
Acta Dermatovenerol Croat. 2013;21(1):52-3.
2
Prolactin and autoimmunity: hyperprolactinemia correlates with serositis and anemia in SLE patients.催乳素与自身免疫：高催乳素血症与 SLE 患者的浆膜炎和贫血相关。
Clin Rev Allergy Immunol. 2012 Apr;42(2):189-98. doi: 10.1007/s12016-011-8256-0.
3
Prolactin's role in the pathogenesis of the antiphospholipid syndrome.催乳素在抗磷脂综合征发病机制中的作用。
Lupus. 2010 Nov;19(13):1515-9. doi: 10.1177/0961203310373781. Epub 2010 Jul 20.
4
Elevation of serum prolactin levels in patients with pemphigus vulgaris: a novel finding with practical implications.寻常型天疱疮患者血清催乳素水平升高：一项具有实际意义的新发现。
J Am Acad Dermatol. 2010 Jun;62(6):1071-2. doi: 10.1016/j.jaad.2009.09.051.
5
Prevalence of autoantibodies to bullous pemphigoid antigens within the normal population.正常人群中针对大疱性类天疱疮抗原的自身抗体患病率。
Arch Dermatol. 2010 Jan;146(1):74-5. doi: 10.1001/archdermatol.2009.324.
6
Hyperprolactinemia and autoimmune diseases.高催乳素血症与自身免疫性疾病。
Autoimmun Rev. 2007 Sep;6(8):537-42. doi: 10.1016/j.autrev.2006.10.005. Epub 2006 Dec 1.
7
Immunopathology and molecular diagnosis of autoimmune bullous diseases.自身免疫性大疱性疾病的免疫病理学与分子诊断
J Cell Mol Med. 2007 May-Jun;11(3):462-81. doi: 10.1111/j.1582-4934.2007.00033.x.
8
Pemphigus vulgaris: recent advances in our understanding of its pathogenesis.寻常型天疱疮：我们对其发病机制认识的最新进展
Minerva Stomatol. 2007 Apr;56(4):215-23.
9
Study of desmoglein 1 and 3 antibody levels in relation to disease severity in Indian patients with pemphigus.印度天疱疮患者中桥粒芯糖蛋白1和3抗体水平与疾病严重程度的关系研究。
Indian J Dermatol Venereol Leprol. 2006 May-Jun;72(3):203-6. doi: 10.4103/0378-6323.25780.
10
Correlation between serum prolactin levels and lupus activity.血清催乳素水平与狼疮活动度之间的相关性。
Rheumatol Int. 2006 Sep;26(11):1036-9. doi: 10.1007/s00296-006-0129-0. Epub 2006 Apr 20.

寻常型天疱疮患者的血清催乳素水平与抗桥粒芯糖蛋白抗体之间是否相关？

Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?

作者信息

Iraji Fariba, Tajmirriahi Nabet, Momeni Iman, Jamshidi Kioumars, Hashemzehi Fazlollah, Siadat Amir Hossein, Esfahani Alireza Asemi

机构信息

Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.

Department of Dermatology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

出版信息

Adv Biomed Res. 2016 Dec 27;5:206. doi: 10.4103/2277-9175.191002. eCollection 2016.

DOI:10.4103/2277-9175.191002
PMID:28217644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5220690/
Abstract

BACKGROUND

Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis. Recent studies showed an etiologic effect for prolactin in the pemphigus vulgaris. This study aimed to quantify the correlation between serum prolactin levels and anti-desmoglein antibodies in patients with pemphigus vulgaris.

MATERIALS AND METHODS

Prolactin and antibodies against desmoglein 1 and 3 measured with ELISA in 14 new subjects of pemphigus vulgaris.

RESULTS

There was no statistically significant relation between both serum prolactin and anti-desmoglein1 levels (r = 0.02, = 0.47) and serum prolactin and anti-desmoglein 3 levels (r= -0.09, = 0.38).

CONCLUSION

This study indicates that no correlation was found between serum prolactin levels and anti-desmoglein 1 levels and serum prolactin and anti-desmoglein 3 levels. However, other studies should be initiated regarding exact molecular and cellular effects of prolactin in the pathogenesis of pemphigus vulgaris.

摘要

背景

寻常型天疱疮是一种皮肤慢性炎症性疾病，其病因尚不完全清楚。尽管如此，抗桥粒芯糖蛋白抗体在发病机制中已被证实发挥作用。最近的研究表明催乳素在寻常型天疱疮中具有病因学作用。本研究旨在量化寻常型天疱疮患者血清催乳素水平与抗桥粒芯糖蛋白抗体之间的相关性。

材料与方法

采用酶联免疫吸附测定法（ELISA）对14例新诊断的寻常型天疱疮患者检测催乳素以及抗桥粒芯糖蛋白1和3抗体。

结果

血清催乳素水平与抗桥粒芯糖蛋白1水平之间（r = 0.02，P = 0.47）以及血清催乳素水平与抗桥粒芯糖蛋白3水平之间（r = -0.09，P = 0.38）均无统计学意义上的相关性。

结论

本研究表明血清催乳素水平与抗桥粒芯糖蛋白1水平以及血清催乳素与抗桥粒芯糖蛋白3水平之间均未发现相关性。然而，关于催乳素在寻常型天疱疮发病机制中确切的分子和细胞效应，应开展其他研究。