寻常型天疱疮患者的血清催乳素水平与抗桥粒芯糖蛋白抗体之间是否相关？
Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?
作者信息
Iraji Fariba, Tajmirriahi Nabet, Momeni Iman, Jamshidi Kioumars, Hashemzehi Fazlollah, Siadat Amir Hossein, Esfahani Alireza Asemi
机构信息
Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Dermatology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
出版信息
Adv Biomed Res. 2016 Dec 27;5:206. doi: 10.4103/2277-9175.191002. eCollection 2016.
BACKGROUND
Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis. Recent studies showed an etiologic effect for prolactin in the pemphigus vulgaris. This study aimed to quantify the correlation between serum prolactin levels and anti-desmoglein antibodies in patients with pemphigus vulgaris.
MATERIALS AND METHODS
Prolactin and antibodies against desmoglein 1 and 3 measured with ELISA in 14 new subjects of pemphigus vulgaris.
RESULTS
There was no statistically significant relation between both serum prolactin and anti-desmoglein1 levels (r = 0.02, = 0.47) and serum prolactin and anti-desmoglein 3 levels (r= -0.09, = 0.38).
CONCLUSION
This study indicates that no correlation was found between serum prolactin levels and anti-desmoglein 1 levels and serum prolactin and anti-desmoglein 3 levels. However, other studies should be initiated regarding exact molecular and cellular effects of prolactin in the pathogenesis of pemphigus vulgaris.
背景
寻常型天疱疮是一种皮肤慢性炎症性疾病，其病因尚不完全清楚。尽管如此，抗桥粒芯糖蛋白抗体在发病机制中已被证实发挥作用。最近的研究表明催乳素在寻常型天疱疮中具有病因学作用。本研究旨在量化寻常型天疱疮患者血清催乳素水平与抗桥粒芯糖蛋白抗体之间的相关性。
材料与方法
采用酶联免疫吸附测定法（ELISA）对14例新诊断的寻常型天疱疮患者检测催乳素以及抗桥粒芯糖蛋白1和3抗体。
结果
血清催乳素水平与抗桥粒芯糖蛋白1水平之间（r = 0.02，P = 0.47）以及血清催乳素水平与抗桥粒芯糖蛋白3水平之间（r = -0.09，P = 0.38）均无统计学意义上的相关性。
结论
本研究表明血清催乳素水平与抗桥粒芯糖蛋白1水平以及血清催乳素与抗桥粒芯糖蛋白3水平之间均未发现相关性。然而，关于催乳素在寻常型天疱疮发病机制中确切的分子和细胞效应，应开展其他研究。
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