Aigbogun Myrlene Sanon, Stellhorn Robert, Krasa Holly, Kostic Dusan
Health Economics and Outcomes Research, Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ, USA.
Global Medical Affairs, Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ, USA.
Alzheimers Dement (Amst). 2017 Apr 20;8:51-59. doi: 10.1016/j.dadm.2017.04.001. eCollection 2017.
Dementia is a prevalent condition in older adults associated with decline in cognitive and functional abilities and substantial burden. This study assessed the prevalence and impact of subjective memory impairment in the United States.
The 2011 to 2014 National Health and Nutrition Examination Survey, a population-based, nationally representative survey, was analyzed. Data included medical examinations, self-reported cognitive and functional limitations, and health care utilization over 1 year. Participants were aged ≥65 years and completed both interview and medical examination components. Descriptive analyses of patient characteristics were performed, and complex survey regression models were used to test associations.
Of 2431 survey participants included, 53.1% had no memory impairment, 40.1% had early-stage memory impairment, and 6.6% had late-stage memory impairment. In adjusted analyses, late-stage versus no impairment was associated with more functional limitations (odds ratio [OR] = 7.26, < .001), greater health care utilization (OR = 2.46, < .001), and higher likelihood of seeing a mental health specialist (OR = 3.06, = .001).
Consistent with previous research, individuals with late-stage memory impairment had significantly greater functional limitations and higher health care utilization versus individuals with early-stage or no memory impairment.
痴呆症在老年人中很常见,与认知和功能能力下降以及沉重负担相关。本研究评估了美国主观记忆障碍的患病率及其影响。
对2011年至2014年全国健康与营养检查调查进行了分析,这是一项基于人群的全国代表性调查。数据包括医学检查、自我报告的认知和功能限制以及1年以上的医疗保健利用情况。参与者年龄≥65岁,完成了访谈和医学检查部分。对患者特征进行了描述性分析,并使用复杂的调查回归模型来检验相关性。
在纳入的2431名调查参与者中,53.1%没有记忆障碍,40.1%有早期记忆障碍,6.6%有晚期记忆障碍。在调整分析中,晚期记忆障碍与无记忆障碍相比,与更多的功能限制相关(优势比[OR]=7.26,P<0.001),更高的医疗保健利用率(OR=2.46,P<0.001),以及看心理健康专家的可能性更高(OR=3.06,P=0.001)。
与先前的研究一致,与早期或无记忆障碍的个体相比,晚期记忆障碍的个体有明显更大的功能限制和更高的医疗保健利用率。