Andrews J Scott, Desai Urvi, Kirson Noam Y, Enloe Caroline J, Ristovska Ljubica, King Sarah, Birnbaum Howard G, Fleisher Adam S, Ye Wenyu, Kahle-Wrobleski Kristin
Global Patient Outcomes and Real World Evidence, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.
Analysis Group, Inc., Boston, MA, USA.
Alzheimers Dement (Amst). 2016 Dec 9;6:65-74. doi: 10.1016/j.dadm.2016.11.005. eCollection 2017.
Little is known about functional limitations and health care resource utilization of people with cognitive impairment with no dementia (CIND).
Respondents with stable or progressive cognitive impairment (CI) after the first (index) indication of CIND in 2000-2010 were identified from the Health and Retirement Study (HRS). Respondents never exhibiting CI were identified as potential controls. Propensity score-based optimal matching was used to adjust for differences in demographics and history of stroke. Differences between cohorts were assessed accounting for HRS survey design.
After matching, CIND respondents had more functional limitations (difficulty with ≥1 activities of daily living: 24% vs. 15%; ≥1 instrumental activities of daily living: 20% vs. 11%) and hospital stays (37% vs. 27%) than respondents with no CI (all < .001). Seventy five percent of CIND respondents developed dementia in the observable follow-up (median time: ∼6 years).
Even before dementia onset, CI is associated with increased likelihood of functional limitations and greater health care resource use.
关于无痴呆的认知障碍(CIND)患者的功能限制和医疗保健资源利用情况,人们了解甚少。
从健康与退休研究(HRS)中识别出2000年至2010年首次(索引)出现CIND后认知障碍(CI)稳定或进展的受访者。从未表现出CI的受访者被确定为潜在对照。使用基于倾向评分的最优匹配来调整人口统计学和中风病史的差异。考虑到HRS调查设计,评估了队列之间的差异。
匹配后,与无CI的受访者相比,CIND受访者有更多的功能限制(≥1项日常生活活动困难:24%对15%;≥1项工具性日常生活活动困难:20%对11%)和住院次数(37%对27%)(所有P<0.001)。在可观察的随访中(中位时间:约6年),75%的CIND受访者发展为痴呆。
即使在痴呆发病之前,CI也与功能限制的可能性增加和更多的医疗保健资源使用相关。