Quiroz Yakeel T, Aguillón David, Arboleda-Velasquez Joseph, Bocanegra Yamile, Cardona-Gómez Gloria Patricia, Corrada Maria M, Diez Ibai, Garcia-Cifuentes Elkin, Kosik Kenneth, Martinez Lusiana, Pineda-Salazar David, Posada Rafael, Roman Norbel, Sepulveda-Falla Diego, Slachevsky Andrea, Soto-Añari Marcio, Tabilo Evelyn, Vasquez Daniel, Villegas-Lanau Andrés
Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.
Boston University Department of Psychological and Brain Sciences, Boston, Massachusetts, USA.
Alzheimers Dement. 2025 Mar;21(3):e70037. doi: 10.1002/alz.70037.
Global life expectancy has steadily increased in recent decades, resulting in a significant rise in the number of individuals aged 80 years and older. This trend is also evident in Latin America, where life expectancy is improving, though at varying rates across countries and regions.
Partnering with the Neurosciences Group of Antioquia (GNA), we launched a Colombian study on resilience in families with autosomal dominant Alzheimer's disease and the oldest-old population. Over the past 2 years, the project has expanded to include participants from Peru, Chile, and Costa Rica.
This research led to the first symposium on Brain Resilience and Healthy Longevity, held in Medellín, Colombia, in August 2024.
The article summarizes key discussions from the symposium, highlighting the most promising opportunities for brain resilience and prevention research in the region and offering recommendations for future research to promote healthy aging and dementia-free communities.
Uncovering the genetic and physiological drivers of cognitive resilience, neurodegeneration resistance, and healthy longevity is essential for maintaining brain function as we age. "Superagers" and cognitively resilient individuals from Latin American families with Alzheimer's disease offer valuable insights into brain protection mechanisms. Studying the interplay of socio-environmental and genetic factors in the oldest-old is key to understanding healthy longevity and improving dementia prevention. The inaugural Brain Resilience and Healthy Longevity Symposium highlights the need for global collaboration to uncover factors that drive cognitive resilience and healthy aging in Latin America, advancing dementia prevention.
近几十年来，全球预期寿命稳步提高，导致80岁及以上的人口数量显著增加。这一趋势在拉丁美洲也很明显，尽管各国和各地区的预期寿命提高速度各不相同，但预期寿命正在改善。
我们与安蒂奥基亚神经科学小组（GNA）合作，在哥伦比亚开展了一项关于常染色体显性阿尔茨海默病家庭和高龄人群复原力的研究。在过去两年中，该项目已扩大到包括来自秘鲁、智利和哥斯达黎加的参与者。
这项研究促成了2024年8月在哥伦比亚麦德林举行的首届脑复原力与健康长寿研讨会。
本文总结了研讨会上的关键讨论内容，突出了该地区脑复原力和预防研究最有前景的机会，并为促进健康老龄化和无痴呆社区的未来研究提供了建议。
揭示认知复原力、神经退行性变抵抗力和健康长寿的遗传和生理驱动因素，对于我们衰老过程中维持脑功能至关重要。来自患有阿尔茨海默病的拉丁美洲家庭的“超级老人”和具有认知复原力的个体，为脑保护机制提供了宝贵的见解。研究高龄人群中社会环境和遗传因素的相互作用，是理解健康长寿和改善痴呆预防的关键。首届脑复原力与健康长寿研讨会强调了全球合作的必要性，以揭示驱动拉丁美洲认知复原力和健康老龄化的因素，推进痴呆预防工作。
