Ndubuisi Chika A, Ohaegbulam Samuel C, Chikani Mark O, Mezue Wilfred C, Mbadugha Tobechi, Okhueleigbe Mark
Department of Neurosurgery, Memfys Hospital for Neurosurgery, Enugu, Nigeria.
Niger Postgrad Med J. 2017 Jan-Mar;24(1):44-47. doi: 10.4103/npmj.npmj_2_17.
Gliomas are important primary brain tumours with varying prognosis.
To study the histology characteristics of brain gliomas managed in a Neurosurgical centre in Nigeria.
A retrospective analysis of prospectively recorded data of patients managed for intracranial gliomas at our Hospital for Neurosurgery, between year 2006 and 2015. Only the patients with conclusive histology diagnosis following surgery were analysed.
Glioma was 23.8% of the 252 histology-confirmed brain tumours. Male-to-female ratio was 1.4:1.0. Peak age at diagnosis was in the fifth decade of life. There was an increase in the frequency of diagnosis from seven (2006-2009) to 15 (2011 and 2012) and 39 patients managed (2013 and 2015). In sub-group analysis, grade IV tumour was the most common (34.6%) followed by grade II (30.7%), grade I (18.3%) and grade III (16.7%). Seven patients of grade II oligodendroglioma and one patient each of anaplastic oligodendroglioma, subependymal giant cell astrocytoma and astroblastoma were seen. The anatomical location of the tumour was the frontal lobe in 23.3% of patients followed by the parietal lobe in 16.7% of patients. The pre-operative Karnofsky score was ≥70% in 36.7% of the patients.
Gliomas are more common brain tumours than were imagined. Most patients present relatively late and with advanced disease. High-grade gliomas seem to mostly affect the middle age population in the study environment with higher proportion of grade IV lesions.
胶质瘤是重要的原发性脑肿瘤，预后各不相同。
研究尼日利亚一家神经外科中心治疗的脑胶质瘤的组织学特征。
对2006年至2015年间在我院神经外科治疗的颅内胶质瘤患者的前瞻性记录数据进行回顾性分析。仅分析术后组织学诊断明确的患者。
胶质瘤占252例组织学确诊脑肿瘤的23.8%。男女比例为1.4:1.0。诊断的高峰年龄在人生的第五个十年。诊断频率从7例（2006 - 2009年）增加到15例（2011年和2012年），以及39例接受治疗的患者（2013年和2015年）。亚组分析中，IV级肿瘤最常见（34.6%），其次是II级（30.7%）、I级（18.3%）和III级（16.7%）。观察到7例II级少突胶质细胞瘤患者，1例间变性少突胶质细胞瘤、室管膜下巨细胞星形细胞瘤和星形母细胞瘤患者。肿瘤的解剖位置在23.3%的患者中位于额叶，其次在16.7%的患者中位于顶叶。36.7%的患者术前卡诺夫斯基评分≥70%。
胶质瘤是比想象中更常见的脑肿瘤。大多数患者就诊时相对较晚且病情已进展。在研究环境中，高级别胶质瘤似乎主要影响中年人群，IV级病变比例更高。
