血脂异常：家族性高胆固醇血症中的 PCSK9 抑制剂和泡沫单核细胞。
Dyslipidaemia: PCSK9 inhibitors and foamy monocytes in familial hypercholesterolaemia.
机构信息
Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, 6565 Fannin Street, MS A601, Houston, Texas 77030, USA.
出版信息
Nat Rev Cardiol. 2017 Jul;14(7):385-386. doi: 10.1038/nrcardio.2017.75. Epub 2017 May 11.
Abstract
Accumulation of foam cells — macrophages with intracellular lipid droplets — in arterial walls is a hallmark of atherosclerosis. Bernelot Moens and colleagues report increases in circulating monocytes with intracellular lipid accumulation, associated CCR2 expression, and enhanced monocyte migration in patients with familial hypercholesterolaemia. These changes could be reversed by PCSK9-inhibitor treatment.
摘要
泡沫细胞（含细胞内脂滴的巨噬细胞）在动脉壁中的堆积是动脉粥样硬化的一个标志。Bernelot Moens 及其同事报道，家族性高胆固醇血症患者循环单核细胞内脂质堆积增加，与 CCR2 表达相关，并增强单核细胞迁移。这些变化可以通过 PCSK9 抑制剂治疗逆转。
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