Branski Ryan C, Rosen Clark A, Verdolini Katherine, Hebda Patricia A
Department of Otolaryngology and University of Pittsburgh Voice Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ann Otol Rhinol Laryngol. 2004 Jan;113(1):23-9. doi: 10.1177/000348940411300105.
This study seeks to determine the ability of enzyme-linked immunosorbent assays of vocal fold secretions to detect and describe the inflammatory response in the vocal folds. Vocal fold and palatal secretions were collected during operation from patients with a range of vocal fold disorders and from control patients. The secretions were subjected to assays for interleukin-1beta, prostaglandin E2, and transforming growth factor beta. The results indicate a differential expression of mediators associated with the wound healing cascade in the vocal folds. The prostaglandin E2 levels clearly differentiated vocal fold secretions associated with laryngeal disease versus control sites. Furthermore, the interleukin-1beta concentrations were significantly elevated in subjects with epithelial lesions of the vocal folds as opposed to lesions of the lamina propria. Although still in its infancy, such analysis may ultimately hold scientific and clinical utility in the study and management of patients with vocal fold disease.
本研究旨在确定声带分泌物的酶联免疫吸附测定法检测和描述声带炎症反应的能力。在手术过程中，从一系列声带疾病患者和对照患者中收集声带和腭部分泌物。对这些分泌物进行白细胞介素-1β、前列腺素E2和转化生长因子β的检测。结果表明，与声带伤口愈合级联相关的介质存在差异表达。前列腺素E2水平清楚地区分了与喉部疾病相关的声带分泌物和对照部位的分泌物。此外，与固有层病变相比，声带上皮病变患者的白细胞介素-1β浓度显著升高。尽管仍处于起步阶段，但这种分析最终可能在声带疾病患者的研究和管理中具有科学和临床应用价值。
