Schieffer Kathleen M, Connor James R, Pawelczyk James A, Sekhar Deepa L
Department of Surgery, Division of Colon and Rectal Surgery, Pennsylvania State University College of Medicine, Hershey.
Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey.
Am J Audiol. 2017 Jun 13;26(2):155-162. doi: 10.1044/2017_AJA-16-0093.
A correlation between iron deficiency anemia (IDA) and sudden sensorineural hearing loss (SNHL) was described in adults. In this study, we examined if there is a relationship between IDA and hearing loss in the pediatric population.
This was a retrospective cohort study of data collected from the Informatics for Integrating Biology and the Bedside database from 2011 to 2016. Children and adolescents 4-21 years old seen at Penn State Milton S. Hershey Medical Center, Hershey, PA, were examined for hearing loss and IDA status. Hearing loss was determined by International Classification of Disease-9 and -10 codes, and IDA was determined by both low hemoglobin and serum ferritin levels for age and sex.
We identified 20,113 patients. Prevalence of hearing loss and IDA was 1.7% and 2.3%, respectively. The prevalence of all hearing loss was 3.0% in the IDA cohort and 1.7% in those without IDA. Children and adolescents with IDA are at increased odds of developing SNHL (adjusted odds ratio: 3.67, 95% CI [1.60-7.30]).
Children with IDA demonstrate increased likelihood of SNHL. Although correction of IDA in those with hearing loss has yet to be linked to improvements in hearing outcomes, screening for and correcting IDA among pediatric patients will positively affect overall health status.
Supplemental Material: https://doi.org/10.23641/asha.5087071.
已有研究描述了成人缺铁性贫血（IDA）与突发性感音神经性听力损失（SNHL）之间的相关性。在本研究中，我们调查了儿科人群中IDA与听力损失之间是否存在关联。
这是一项回顾性队列研究，数据来自2011年至2016年的生物与床边信息整合数据库。对宾夕法尼亚州赫尔希市宾夕法尼亚州立大学米尔顿·S·赫尔希医疗中心就诊的4至21岁儿童和青少年进行听力损失和IDA状况检查。听力损失通过国际疾病分类第9版和第10版编码确定，IDA通过年龄和性别的低血红蛋白和血清铁蛋白水平确定。
我们共纳入20113名患者。听力损失和IDA的患病率分别为1.7%和2.3%。IDA队列中所有听力损失的患病率为3.0%，无IDA者为1.7%。患有IDA的儿童和青少年发生SNHL的几率增加（调整后的优势比：3.67，95%置信区间[1.60 - 7.30]）。
患有IDA的儿童发生SNHL的可能性增加。尽管听力损失患者中IDA的纠正与听力结果的改善尚未建立联系，但对儿科患者进行IDA筛查和纠正将对整体健康状况产生积极影响。
