Department of Pharmacy Practice, Tri-Service General Hospital, Taipei 11490, Taiwan.
School of Pharmacy, National Defense Medical Center, Taipei 11490, Taiwan.
Int J Environ Res Public Health. 2020 Jun 1;17(11):3916. doi: 10.3390/ijerph17113916.
Existing evidence indicates that both iron deficiency anemia and sickle cell anemia have been previously associated with hearing loss. However, human data investigating the association between anemia and auditory threshold shifts at different frequencies in the adolescent, adult and elderly population are extremely limited to date. Therefore, this cross-sectional study used the dataset from the US National Health and Nutrition Examination Survey from 2005 to 2012 to explore differences in low- or high-frequency hearing thresholds and hearing loss prevalence between participants with and without anemia. A total of 918 patients with anemia and 8213 without anemia were included. Results indicated that low- and high-frequency pure tone average were significantly higher in patients with anemia than that in those without anemia in the elderly, but not in adult or adolescent population. In addition, the prevalence of low-frequency hearing loss but not high-frequency hearing loss was also higher in patients with anemia than in those without anemia in the elderly population. After adjusting various confounders, multiple regression models still indicated that patients with anemia tended to have larger threshold shift. In conclusion, anemia was associated with auditory threshold shifts in the elderly population, especially those vulnerable to low-frequency hearing loss.
现有证据表明，缺铁性贫血和镰状细胞贫血以前都与听力损失有关。然而，迄今为止，人类数据对于调查青少年、成年和老年人群体中不同频率的贫血与听阈偏移之间的关系非常有限。因此，这项横断面研究使用了美国国家健康和营养调查 2005 年至 2012 年的数据，来探讨贫血患者与非贫血患者之间低频和高频听阈差异以及听力损失患病率的差异。共纳入 918 例贫血患者和 8213 例非贫血患者。结果表明，在老年人中，贫血患者的低频和高频纯音平均听阈明显高于非贫血患者，但在成年或青少年人群中则没有差异。此外，贫血患者低频听力损失的患病率高于非贫血患者，而高频听力损失的患病率则没有差异。在调整了各种混杂因素后，多元回归模型仍表明贫血患者的听力阈值偏移更大。综上所述，贫血与老年人群体的听觉阈移有关，尤其是低频听力损失。
