Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Comparative Biomedical Sciences Graduate Program, Neurosciences Concentration Area, North Carolina State University, Raleigh, NC, USA.
FEBS Lett. 2017 Dec;591(24):4009-4026. doi: 10.1002/1873-3468.12676. Epub 2017 Aug 21.
Development of the cerebral cortices depends on tight regulation of cell divisions. In this system, stem and progenitor cells undergo symmetric and asymmetric divisions to ultimately produce neurons that establish the layers of the cortex. Cell division culminates with the formation of the midbody, a transient organelle that establishes the site of abscission between nascent daughter cells. During cytokinetic abscission, the final stage of cell division, one daughter cell will inherit the midbody remnant, which can then maintain or expel the remnant, but mechanisms and circumstances influencing this decision are unclear. This review describes the midbody and its constituent proteins, as well as the known consequences of their manipulation during cortical development. The potential functional relevance of midbody mechanisms is discussed.
大脑皮层的发育依赖于细胞分裂的紧密调控。在这个系统中，干细胞和祖细胞经历对称和不对称分裂，最终产生神经元，建立皮层的层。细胞分裂以中体的形成达到高潮，中体是一个短暂的细胞器，在新生子细胞之间建立分离的位点。在胞质分裂的分离阶段，即细胞分裂的最后阶段，一个子细胞将继承中体残余物，然后可以保留或排出残余物，但影响这一决定的机制和情况尚不清楚。本综述描述了中体及其组成蛋白，以及在皮质发育过程中对其进行操作的已知后果。讨论了中体机制的潜在功能相关性。
