Jao Nancy C, Veluz-Wilkins Anna K, Smith Matthew J, Carroll Allison J, Blazekovic Sonja, Leone Frank T, Tyndale Rachel F, Schnoll Robert A, Hitsman Brian
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine.
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine.
Exp Clin Psychopharmacol. 2017 Jun;25(3):216-222. doi: 10.1037/pha0000124.
The nicotine metabolite ratio (NMR) has been shown to predict response to the transdermal nicotine patch, such that faster nicotine metabolism is associated with a lower abstinence rate. Menthol cigarette use, versus nonmenthol cigarette use, slows nicotine metabolism and therefore may attenuate the effect of NMR on smoking abstinence. In this study, we evaluated whether cigarette type (menthol vs. nonmenthol) modified the association between NMR and short-term abstinence. This was a secondary analysis examining treatment in the first 8 weeks of 21 mg/day nicotine patch therapy in a completed clinical trial (n = 474). Menthol cigarette use was based on self-report. NMR was defined dichotomously (0 = fast, 1 = slow) to distinguish between fast (≥0.47) versus slow NMR. Using logistic regression analysis, we tested whether cigarette type moderated the association between NMR and bioverified 7-day point prevalence abstinence at Week 8. Covariates include nicotine dependence, age, race, and gender. Three hundred two participants reported smoking menthol cigarettes, of which 234 (77%) were classified as slow NMR. Among the 172 nonmenthol smokers, 136 were classified as slow NMR (79%). Contrary to our expectations, the NMR ×Cigarette Type interaction effect on abstinence was not significant (odds ratio [OR] = 0.91, p = .86). Excluding the interaction variable, fast NMR was associated with decreased likelihood of abstinence (OR = 0.55, p = .03), but menthol cigarette use was not (OR = 1.15, p = .56). Further exploration of risk factors among menthol cigarette smokers, especially among racially diverse and light smokers, could clarify the association between menthol cigarette use and poorer smoking outcomes. (PsycINFO Database Record
尼古丁代谢物比率（NMR）已被证明可预测对经皮尼古丁贴片的反应，即尼古丁代谢越快，戒断率越低。与使用非薄荷醇香烟相比，使用薄荷醇香烟会减缓尼古丁代谢，因此可能会减弱NMR对戒烟的影响。在本研究中，我们评估了香烟类型（薄荷醇香烟与非薄荷醇香烟）是否会改变NMR与短期戒断之间的关联。这是一项二次分析，在一项已完成的临床试验（n = 474）中，对每天21毫克尼古丁贴片治疗的前8周的治疗情况进行检查。薄荷醇香烟的使用基于自我报告。NMR被二分法定义（0 = 快，1 = 慢），以区分快速NMR（≥0.47）与慢速NMR。使用逻辑回归分析，我们测试了香烟类型是否调节了NMR与第8周经生物验证的7天点患病率戒断之间的关联。协变量包括尼古丁依赖、年龄、种族和性别。302名参与者报告使用薄荷醇香烟，其中234名（77%）被归类为慢速NMR。在172名非薄荷醇吸烟者中，136名被归类为慢速NMR（79%）。与我们的预期相反，NMR×香烟类型对戒断的交互作用不显著（优势比[OR] = 0.91，p = 0.86）。排除交互变量后，快速NMR与戒断可能性降低相关（OR = 0.55，p = 0.03），但使用薄荷醇香烟则不然（OR = 1.15，p = 0.56）。进一步探索薄荷醇香烟吸烟者中的危险因素，尤其是在种族多样化的轻度吸烟者中，可能会阐明使用薄荷醇香烟与较差吸烟结果之间的关联。（PsycINFO数据库记录）
