Park Jae Won, Oh Se An, Yea Ji Woon, Kang Min Kyu
Department of Radiation Oncology, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu, South Korea.
Department of Radiation Oncology, Kyungpook National University School of Medicine, 807 Hoguk-ro, Buk-gu, Daegu, South Korea.
PLoS One. 2017 May 11;12(5):e0177562. doi: 10.1371/journal.pone.0177562. eCollection 2017.
A three-dimensional (3D)-printed customized bolus (3D bolus) can be used for radiotherapy application to irregular surfaces. However, bolus fabrication based on computed tomography (CT) scans is complicated and also delivers unwanted irradiation. Consequently, we fabricated a bolus using a 3D scanner and evaluated its efficacy. The head of an Alderson Rando phantom was scanned with a 3D scanner. The 3D surface data were exported and reconstructed with Geomagic Design X software. A 3D bolus of 5-mm thickness designed to fit onto the nose was printed with the use of rubber-like printing material, and a radiotherapy plan was developed. We successfully fabricated the customized 3D bolus, and further, a CT simulation indicated an acceptable fit of the 3D bolus to the nose. There was no air gap between the bolus and the phantom surface. The percent depth dose (PDD) curve of the phantom with the 3D bolus showed an enhanced surface dose when compared with that of the phantom without the bolus. The PDD of the 3D bolus was comparable with that of a commercial superflab bolus. The radiotherapy plan considering the 3D bolus showed improved target coverage when compared with that without the bolus. Thus, we successfully fabricated a customized 3D bolus for an irregular surface using a 3D scanner instead of a CT scanner.
三维（3D）打印定制的组织填充物（3D组织填充物）可用于对不规则表面进行放射治疗。然而，基于计算机断层扫描（CT）扫描制作组织填充物很复杂，并且还会产生不必要的辐射。因此，我们使用3D扫描仪制作了一种组织填充物并评估了其效果。使用3D扫描仪对Alderson Rando人体模型的头部进行扫描。导出3D表面数据并用Geomagic Design X软件进行重建。使用类似橡胶的打印材料打印出一个厚度为5毫米、设计用于贴合鼻子的3D组织填充物，并制定了放射治疗计划。我们成功制作出了定制的3D组织填充物，此外，CT模拟表明3D组织填充物与鼻子的贴合度可以接受。组织填充物与人体模型表面之间没有气隙。与没有组织填充物的人体模型相比，带有3D组织填充物的人体模型的百分深度剂量（PDD）曲线显示表面剂量有所增加。3D组织填充物的PDD与商用超软组织填充物的PDD相当。与没有组织填充物的放射治疗计划相比，考虑了3D组织填充物的放射治疗计划显示靶区覆盖情况有所改善。因此，我们成功地使用3D扫描仪而非CT扫描仪为不规则表面制作了定制的3D组织填充物。
