Ehrlich Laura, Hoeller Alice, Golic Michaela, Herse Florian, Perschel Frank H, Henrich Wolfgang, Dechend Ralf, Huppertz Berthold, Verlohren Stefan
a Department of Obstetrics , Campus Virchow-Clinic, Charite´ University Medicine , Berlin , Germany.
b Experimental and Clinical Research Center , Medical Faculty of the Charité and Max-Delbrueck Center for Molecular Medicine , Berlin , Germany.
Hypertens Pregnancy. 2017 May;36(2):175-185. doi: 10.1080/10641955.2017.1291673. Epub 2017 May 11.
To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF).
Placental tissues and maternal blood samples from seven patients with PE, five IUGR, and seven age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity.
Placental PlGF mRNA and protein expression were not altered by placental dysfunction while placental villous trophoblast expression intensity of PlGF was increased.
High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.
探讨晚发型子痫前期（PE）与胎儿生长受限（IUGR）之间的差异是否可通过可溶性血管内皮生长因子受体1（sFlt-1）、血管内皮生长因子受体1（Flt-1）和胎盘生长因子（PlGF）的胎盘表达模式差异来解释。
对7例子痫前期患者、5例胎儿生长受限患者及7例年龄匹配的对照者的胎盘组织和母血样本进行mRNA和蛋白水平以及蛋白定位和表达强度研究。
胎盘功能障碍未改变胎盘PlGF mRNA和蛋白表达，但胎盘绒毛滋养层PlGF表达强度增加。
高浓度sFlt-1可能是导致母血清PlGF水平降低的原因。
