Hoeller Alice, Ehrlich Laura, Golic Michaela, Herse Florian, Perschel Frank H, Siwetz Monika, Henrich Wolfgang, Dechend Ralf, Huppertz Berthold, Verlohren Stefan
a Department of Obstetrics , Charité University Medicine , Berlin , Germany.
b HELIOS Clinic, Experimental and Clinical Research Center, Max-Delbrueck Center , Berlin-Buch , Germany.
Hypertens Pregnancy. 2017 May;36(2):151-160. doi: 10.1080/10641955.2016.1273363. Epub 2017 Feb 10.
To investigate whether differences between early preeclampsia and early fetal growth restriction can be explained by differential placental expression patterns of sFlt-1, Flt-1, and PlGF.
Placental tissues and maternal blood samples from six cases of preeclampsia, seven IUGR, and six age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity.
Neither placental PlGF mRNA and protein expression nor placental villous trophoblast expression intensity of PlGF was altered by placental dysfunction.
High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.
研究早发型子痫前期与早发型胎儿生长受限之间的差异是否可通过可溶性血管内皮生长因子受体-1（sFlt-1）、血管内皮生长因子受体-1（Flt-1）和胎盘生长因子（PlGF）不同的胎盘表达模式来解释。
对6例子痫前期患者、7例胎儿生长受限患者及6例年龄匹配的对照组的胎盘组织和母血样本进行研究，检测其mRNA和蛋白水平以及蛋白定位和表达强度。
胎盘功能障碍并未改变胎盘PlGF mRNA和蛋白表达，也未改变胎盘绒毛滋养层细胞中PlGF的表达强度。
高浓度的sFlt-1可能是导致孕妇血清PlGF水平降低的原因。
