HIV潜伏获得新的组蛋白标记。
HIV Latency Gets a New Histone Mark.
作者信息
Nikolai Bryan C, Feng Qin
机构信息
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Cell Host Microbe. 2017 May 10;21(5):549-550. doi: 10.1016/j.chom.2017.04.012.
Abstract
Transcriptional latency of integrated HIV-1 provirus represents a major obstacle to curing HIV. In this issue of Cell Host & Microbe, Boehm et al. (2017) identify a new lysine methyltransferase that writes a repressive histone mark associated with HIV-1 latency. The results are important for strategies to pharmacologically reverse HIV-1 latency.
摘要
整合的HIV-1前病毒的转录潜伏期是治愈HIV的主要障碍。在本期《细胞宿主与微生物》中， Boehm等人（2017年）鉴定出一种新的赖氨酸甲基转移酶，该酶会产生与HIV-1潜伏期相关的抑制性组蛋白标记。这些结果对于从药理学角度逆转HIV-1潜伏期的策略具有重要意义。
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