Wang Zihang, Zhang Yuhong, Liu Weiwei, Su Benli
Department of Diagnostic Ultrasound, Second Affiliated Hospital of Dalian Medical University, Dalian, P. R. China.
Library of Dalian Medical University, Dalian, P. R. China.
Exp Clin Endocrinol Diabetes. 2017 Oct;125(9):598-602. doi: 10.1055/s-0042-114035. Epub 2017 May 11.
The present study aimed to evaluate the diagnostic value of echocardiography in measuring the thickness of epicardial adipose tissue (EAT) of the patients of type 2 diabetes mellitus (T2DM) and its correlation with the intimal-medial thickness of the carotid artery (cIMT) to investigate the relationship between EAT and cIMT. 68 patients of T2DM were enrolled and were divided into 2 groups: group of T2DM with duration≤10 years (35 cases) and group of T2DM with duration>10 years (33 cases). And 30 healthy subjects were enrolled as the control group. The thickness of EAT and cIMT were measured by echocardiography and high-frequency ultrasonography. The thickness of EAT and IMT of the carotid artery of 2 type 2 diabetic groups (duration≤10 years and>10 years) were significantly higher than that of the control group (all p<0.05), and the thickness of EAT and cIMT of the group of T2DM with duration>10 years were significantly higher than that of the group of T2DM with duration≤10 years (p<0.05). In univariate analysis, the thickness of EAT was positively and significantly associated with age (r0412, p005), BMI r0566, p005), waist circumference (r075, p005), LDL (r0425, p005), TG (r0496, p005), duration of diabetes (r=0.384, p<0.05 and cIMT (r0456, p005). In multiple stepwise regression analyses, age, BMI and IMT of carotid artery were appeared to be significantly associated with EAT (p<0.05 for all). In conclusion, routine screening of EAT and cIMT by ultrasonography in type 2 diabetic patients helps us to predict cardiovascular risks and prevent further development of cardiovascular complications.
本研究旨在评估超声心动图测量2型糖尿病（T2DM）患者心外膜脂肪组织（EAT）厚度的诊断价值及其与颈动脉内膜中层厚度（cIMT）的相关性，以探讨EAT与cIMT之间的关系。纳入68例T2DM患者，分为两组：糖尿病病程≤10年组（35例）和糖尿病病程>10年组（33例）。另纳入30例健康受试者作为对照组。采用超声心动图和高频超声测量EAT厚度和cIMT。2型糖尿病两组（病程≤10年和>10年）的EAT厚度和颈动脉IMT均显著高于对照组（均p<0.05），且糖尿病病程>10年组的EAT厚度和cIMT显著高于糖尿病病程≤10年组（p<0.05）。单因素分析中，EAT厚度与年龄（r=0.412，p=0.05）、BMI（r=0.566，p=0.05）、腰围（r=0.75，p=0.05）、低密度脂蛋白（r=0.425，p=0.05）、甘油三酯（r=0.496，p=0.05）、糖尿病病程（r=0.384，p<0.05）和cIMT（r=0.456，p=0.05）呈显著正相关。多因素逐步回归分析显示，年龄、BMI和颈动脉IMT与EAT显著相关（均p<0.05）。总之，对2型糖尿病患者进行超声心动图常规筛查EAT和cIMT有助于预测心血管风险并预防心血管并发症的进一步发展。
